FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008505102> ?p ?o ?g. }

• W2008505102 endingPage "501" @default.
• W2008505102 startingPage "495" @default.
• W2008505102 abstract "Complement activation contributes to tissue injury in various forms of glomerulopathy and is characterized by deposition of complement components, which accelerates the progression of chronic renal damage. We recently reported that complement 3 (C3), a critical component of the complement system, is associated with the synthetic phenotype of vascular smooth muscle cells. It is possible that C3 stimulates mesangial cells to assume the synthetic phenotype to, in turn, induce glomerular injury and sclerosis. We investigated the role of C3 in the growth and phenotype of mesangial cells. Cultured human mesangial cells (HMCs) expressed C3 mRNA and protein, and levels were increased in response to IFN-gamma and TNF-alpha. HMCs also expressed C3a receptor mRNA and protein. Exogenous C3a stimulated DNA synthesis in HMCs in a dose-dependent manner. C3a decreased expression h-caldesmon mRNA, a marker of the contractile phenotype, and increased the expression of osteopontin, matrix Gla, and collagen type1 alpha1 (collagen IV) mRNAs, which are markers of the synthetic phenotype. C3a decreased expression of alpha-smooth muscle actin in HMCs. Small interfering RNA (siRNA) targeting C3 reduced the DNA synthesis and proliferation of HMCs, increased expression of h-caldesmon mRNA, and decreased expression of osteopontin, matrix Gla, and collagen IV mRNAs in HMCs. These results indicate that C3 causes HMCs to convert to the synthetic phenotype and stimulates growth of mesangial cells, suggesting that C3 may play an important role in phenotypic regulation of mesangial cells in renal diseases." @default.
• W2008505102 created "2016-06-24" @default.
• W2008505102 creator A5000870378 @default.
• W2008505102 creator A5008312853 @default.
• W2008505102 creator A5021979476 @default.
• W2008505102 creator A5036716509 @default.
• W2008505102 creator A5053312419 @default.
• W2008505102 creator A5056507673 @default.
• W2008505102 creator A5057302927 @default.
• W2008505102 creator A5080815038 @default.
• W2008505102 date "2007-01-01" @default.
• W2008505102 modified "2023-09-24" @default.
• W2008505102 title "Complement 3 is involved in changing the phenotype of human glomerular mesangial cells" @default.
• W2008505102 cites W111509703 @default.
• W2008505102 cites W1493031501 @default.
• W2008505102 cites W1606868561 @default.
• W2008505102 cites W1865845936 @default.
• W2008505102 cites W1967731092 @default.
• W2008505102 cites W1979866508 @default.
• W2008505102 cites W1985918311 @default.
• W2008505102 cites W1986382117 @default.
• W2008505102 cites W1989841062 @default.
• W2008505102 cites W1999983218 @default.
• W2008505102 cites W2008273006 @default.
• W2008505102 cites W2015493324 @default.
• W2008505102 cites W2021416375 @default.
• W2008505102 cites W2032079691 @default.
• W2008505102 cites W2034961019 @default.
• W2008505102 cites W2040275693 @default.
• W2008505102 cites W2040496194 @default.
• W2008505102 cites W2040536490 @default.
• W2008505102 cites W2045904371 @default.
• W2008505102 cites W2046033895 @default.
• W2008505102 cites W2048681283 @default.
• W2008505102 cites W2049726553 @default.
• W2008505102 cites W2050288935 @default.
• W2008505102 cites W2056441426 @default.
• W2008505102 cites W2078663145 @default.
• W2008505102 cites W2108946846 @default.
• W2008505102 cites W2124864831 @default.
• W2008505102 cites W2136131868 @default.
• W2008505102 cites W2137570167 @default.
• W2008505102 cites W2167978636 @default.
• W2008505102 cites W2174093581 @default.
• W2008505102 cites W3142447781 @default.
• W2008505102 cites W4377428302 @default.
• W2008505102 doi "https://doi.org/10.1002/jcp.21129" @default.
• W2008505102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17520688" @default.
• W2008505102 hasPublicationYear "2007" @default.
• W2008505102 type Work @default.
• W2008505102 sameAs 2008505102 @default.
• W2008505102 citedByCount "44" @default.
• W2008505102 countsByYear W20085051022012 @default.
• W2008505102 countsByYear W20085051022013 @default.
• W2008505102 countsByYear W20085051022014 @default.
• W2008505102 countsByYear W20085051022015 @default.
• W2008505102 countsByYear W20085051022016 @default.
• W2008505102 countsByYear W20085051022017 @default.
• W2008505102 countsByYear W20085051022018 @default.
• W2008505102 countsByYear W20085051022019 @default.
• W2008505102 countsByYear W20085051022020 @default.
• W2008505102 countsByYear W20085051022021 @default.
• W2008505102 countsByYear W20085051022022 @default.
• W2008505102 countsByYear W20085051022023 @default.
• W2008505102 crossrefType "journal-article" @default.
• W2008505102 hasAuthorship W2008505102A5000870378 @default.
• W2008505102 hasAuthorship W2008505102A5008312853 @default.
• W2008505102 hasAuthorship W2008505102A5021979476 @default.
• W2008505102 hasAuthorship W2008505102A5036716509 @default.
• W2008505102 hasAuthorship W2008505102A5053312419 @default.
• W2008505102 hasAuthorship W2008505102A5056507673 @default.
• W2008505102 hasAuthorship W2008505102A5057302927 @default.
• W2008505102 hasAuthorship W2008505102A5080815038 @default.
• W2008505102 hasConcept C104317684 @default.
• W2008505102 hasConcept C105580179 @default.
• W2008505102 hasConcept C111684460 @default.
• W2008505102 hasConcept C126322002 @default.
• W2008505102 hasConcept C127716648 @default.
• W2008505102 hasConcept C134018914 @default.
• W2008505102 hasConcept C153911025 @default.
• W2008505102 hasConcept C159654299 @default.
• W2008505102 hasConcept C181199279 @default.
• W2008505102 hasConcept C189165786 @default.
• W2008505102 hasConcept C203014093 @default.
• W2008505102 hasConcept C2779131090 @default.
• W2008505102 hasConcept C2779360546 @default.
• W2008505102 hasConcept C2780091579 @default.
• W2008505102 hasConcept C2780804394 @default.
• W2008505102 hasConcept C29688787 @default.
• W2008505102 hasConcept C55493867 @default.
• W2008505102 hasConcept C71924100 @default.
• W2008505102 hasConcept C86803240 @default.
• W2008505102 hasConcept C95444343 @default.
• W2008505102 hasConceptScore W2008505102C104317684 @default.
• W2008505102 hasConceptScore W2008505102C105580179 @default.
• W2008505102 hasConceptScore W2008505102C111684460 @default.
• W2008505102 hasConceptScore W2008505102C126322002 @default.
• W2008505102 hasConceptScore W2008505102C127716648 @default.

• next