Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008507118> ?p ?o ?g. }
- W2008507118 endingPage "147" @default.
- W2008507118 startingPage "141" @default.
- W2008507118 abstract "The efficacy of a potential therapeutic vaccine against chronic hepatitis B virus (HBV) infection depends on the development of strong and multi-specific T cell responses. The potency of CD8+ cytotoxic T lymphocyte (CTL) responses toward HBV core antigen (HBcAg) has been shown to be critical for the outcomes of HBV chronic infection. In this study we have identified a previously undescribed HLA-A*0201-restricted HBcAg-specific CTL epitope (HBcAg64–72, C64–72, ELMTLATWV). T2 binding assay showed that C64–72 had high affinity to HLA-A*0201 molecule. Functionally, the peptide C64–72 could induce peptide-specific CTLs both in vivo (HLA-A2.1/Kb transgenic mice) and in vitro (PBLs of healthy HLA-A2.1+ donors), as demonstrated by interferon-γ (IFN-γ) secretion upon stimulation with C64–72-pulsed T2 cells or autologous human dendritic cells (DCs) respectively. HLA-A*0201-C64–72 tetramer staining revealed the presence of a significant population of C64–72-specific CTLs in C64–72-stimulated CD8+ T cells. Furthermore, the peptide-specific cytotoxic reactivity and the production of perforin and granzyme B of CTLs also increased after stimulation with C64–72-pulsed autologous DCs. These results indicate that the newly identified epitope C64–72 has potential to be used in the development of immunotherapeutic approaches to HBV infection." @default.
- W2008507118 created "2016-06-24" @default.
- W2008507118 creator A5039161381 @default.
- W2008507118 creator A5058169135 @default.
- W2008507118 creator A5058420472 @default.
- W2008507118 creator A5072588823 @default.
- W2008507118 creator A5077465653 @default.
- W2008507118 date "2012-06-01" @default.
- W2008507118 modified "2023-10-10" @default.
- W2008507118 title "Identification of HLA-A*0201-restricted CD8+ T-cell epitope C64–72 from hepatitis B virus core protein" @default.
- W2008507118 cites W1585454606 @default.
- W2008507118 cites W1716038830 @default.
- W2008507118 cites W1817144267 @default.
- W2008507118 cites W1963563273 @default.
- W2008507118 cites W1964862727 @default.
- W2008507118 cites W1965629919 @default.
- W2008507118 cites W1966851944 @default.
- W2008507118 cites W1971321663 @default.
- W2008507118 cites W1976653428 @default.
- W2008507118 cites W1978253514 @default.
- W2008507118 cites W1979408635 @default.
- W2008507118 cites W1985262993 @default.
- W2008507118 cites W1992984968 @default.
- W2008507118 cites W1995561333 @default.
- W2008507118 cites W2006057225 @default.
- W2008507118 cites W2008890570 @default.
- W2008507118 cites W2011555137 @default.
- W2008507118 cites W2015504393 @default.
- W2008507118 cites W2028290473 @default.
- W2008507118 cites W2042204926 @default.
- W2008507118 cites W2043056723 @default.
- W2008507118 cites W2046387499 @default.
- W2008507118 cites W2048858051 @default.
- W2008507118 cites W2056228682 @default.
- W2008507118 cites W2056280345 @default.
- W2008507118 cites W2063511434 @default.
- W2008507118 cites W2075237518 @default.
- W2008507118 cites W2080980504 @default.
- W2008507118 cites W2088165891 @default.
- W2008507118 cites W2095253071 @default.
- W2008507118 cites W2095807554 @default.
- W2008507118 cites W2096808350 @default.
- W2008507118 cites W2098364796 @default.
- W2008507118 cites W2100069498 @default.
- W2008507118 cites W2100587714 @default.
- W2008507118 cites W2100853445 @default.
- W2008507118 cites W2100933843 @default.
- W2008507118 cites W2118434108 @default.
- W2008507118 cites W2131605289 @default.
- W2008507118 cites W2132694288 @default.
- W2008507118 cites W2143369248 @default.
- W2008507118 cites W2155599296 @default.
- W2008507118 cites W2157098396 @default.
- W2008507118 cites W2164339006 @default.
- W2008507118 cites W2166831581 @default.
- W2008507118 cites W2169403803 @default.
- W2008507118 cites W2175117246 @default.
- W2008507118 cites W23185223 @default.
- W2008507118 cites W2437848512 @default.
- W2008507118 cites W4256305261 @default.
- W2008507118 doi "https://doi.org/10.1016/j.intimp.2012.03.018" @default.
- W2008507118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22480777" @default.
- W2008507118 hasPublicationYear "2012" @default.
- W2008507118 type Work @default.
- W2008507118 sameAs 2008507118 @default.
- W2008507118 citedByCount "13" @default.
- W2008507118 countsByYear W20085071182014 @default.
- W2008507118 countsByYear W20085071182016 @default.
- W2008507118 countsByYear W20085071182018 @default.
- W2008507118 countsByYear W20085071182019 @default.
- W2008507118 countsByYear W20085071182020 @default.
- W2008507118 countsByYear W20085071182021 @default.
- W2008507118 countsByYear W20085071182022 @default.
- W2008507118 countsByYear W20085071182023 @default.
- W2008507118 crossrefType "journal-article" @default.
- W2008507118 hasAuthorship W2008507118A5039161381 @default.
- W2008507118 hasAuthorship W2008507118A5058169135 @default.
- W2008507118 hasAuthorship W2008507118A5058420472 @default.
- W2008507118 hasAuthorship W2008507118A5072588823 @default.
- W2008507118 hasAuthorship W2008507118A5077465653 @default.
- W2008507118 hasConcept C147483822 @default.
- W2008507118 hasConcept C154317977 @default.
- W2008507118 hasConcept C159047783 @default.
- W2008507118 hasConcept C167672396 @default.
- W2008507118 hasConcept C195616568 @default.
- W2008507118 hasConcept C202751555 @default.
- W2008507118 hasConcept C203014093 @default.
- W2008507118 hasConcept C2522874641 @default.
- W2008507118 hasConcept C2777410769 @default.
- W2008507118 hasConcept C2779729466 @default.
- W2008507118 hasConcept C2780380082 @default.
- W2008507118 hasConcept C2780593183 @default.
- W2008507118 hasConcept C55493867 @default.
- W2008507118 hasConcept C86803240 @default.
- W2008507118 hasConceptScore W2008507118C147483822 @default.
- W2008507118 hasConceptScore W2008507118C154317977 @default.
- W2008507118 hasConceptScore W2008507118C159047783 @default.
- W2008507118 hasConceptScore W2008507118C167672396 @default.