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- W2008515265 endingPage "451" @default.
- W2008515265 startingPage "426" @default.
- W2008515265 abstract "Over the past three decades, a large body of work has been directed at the development of therapeutic cytokines. Despite their central role in immune modulation, only a handful of cytokine therapeutics has achieved regulatory approval. One of the major challenges associated with the therapeutic use of cytokines relates to their short serum half-life and low bioavailability. High doses are required to overcome these problems, which often result in dose-limiting toxicities. Consequently, most cytokines require protein engineering approaches to reduce toxicity and increase half-life. For this purpose, PEGylation, fusion proteins, antibody complexes and mutagenesis have been utilized. Here, we summarize past, recent and emerging strategies in this area." @default.
- W2008515265 created "2016-06-24" @default.
- W2008515265 creator A5000689999 @default.
- W2008515265 creator A5008724686 @default.
- W2008515265 creator A5036433120 @default.
- W2008515265 date "2013-07-03" @default.
- W2008515265 modified "2023-09-29" @default.
- W2008515265 title "Molecular Engineering of Therapeutic Cytokines" @default.
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