FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008516711> ?p ?o ?g. }

• W2008516711 endingPage "327" @default.
• W2008516711 startingPage "321" @default.
• W2008516711 abstract "The polymorphic human cytochrome P450 2A6 (CYP2A6) metabolises a number of drugs, activates a variety of precarcinogens and constitutes the major nicotine C ‐oxidase. A relationship between CYP2A6 genotype and smoking habits, as well as incidence of lung cancer, has been proposed. Two defective alleles have hitherto been identified, one of which is very common in Asian populations. Among Caucasians, an additional defective and frequently distributed allele ( CYP2A6*3 ) has been suggested to play a protective role against nicotine addiction and cigarette consumption. Here, we have re‐evaluated the genotyping method used for the CYP2A6*3 allele and found that a gene conversion in the 3′ flanking region of 30–40% of CYP2A6*1 alleles results in genotype misclassification. In fact, no true CYP2A6*3 alleles were found among 100 Spaniards and 96 Chinese subjects. In one Spanish poor metaboliser of the CYP2A6 probe drug coumarin, we found two novel defective alleles. One, CYP2A6*5 , encoded an unstable enzyme having a G479L substitution and the other was found to carry a novel type of CYP2A6 gene deletion ( CYP2A6*4D) . The results imply the presence of numerous defective as well as active CYP2A6 alleles as a consequence of CYP2A6/CYP2A7 gene conversion events. We conclude that molecular epidemiological studies concerning CYP2A6 require validated genotyping methods for accurate detection of all known defective CYP2A6 alleles." @default.
• W2008516711 created "2016-06-24" @default.
• W2008516711 creator A5012663065 @default.
• W2008516711 creator A5014446196 @default.
• W2008516711 creator A5015580338 @default.
• W2008516711 creator A5017003826 @default.
• W2008516711 creator A5059817627 @default.
• W2008516711 creator A5062146319 @default.
• W2008516711 creator A5081399911 @default.
• W2008516711 creator A5083839545 @default.
• W2008516711 creator A5086761257 @default.
• W2008516711 date "1999-10-25" @default.
• W2008516711 modified "2023-10-17" @default.
• W2008516711 title "Identification and characterisation of novel polymorphisms in the <i>CYP2A</i> locus: implications for nicotine metabolism" @default.
• W2008516711 cites W1271537196 @default.
• W2008516711 cites W1498118152 @default.
• W2008516711 cites W1498652161 @default.
• W2008516711 cites W1675823061 @default.
• W2008516711 cites W1775749144 @default.
• W2008516711 cites W1951469402 @default.
• W2008516711 cites W1985940725 @default.
• W2008516711 cites W1987888101 @default.
• W2008516711 cites W1996646230 @default.
• W2008516711 cites W1998984889 @default.
• W2008516711 cites W1999647556 @default.
• W2008516711 cites W2007054543 @default.
• W2008516711 cites W2007972960 @default.
• W2008516711 cites W2011826075 @default.
• W2008516711 cites W2022486010 @default.
• W2008516711 cites W2024171602 @default.
• W2008516711 cites W2025269545 @default.
• W2008516711 cites W2036264497 @default.
• W2008516711 cites W2041127681 @default.
• W2008516711 cites W2048808087 @default.
• W2008516711 cites W2051062958 @default.
• W2008516711 cites W2051725346 @default.
• W2008516711 cites W2055139096 @default.
• W2008516711 cites W2064695558 @default.
• W2008516711 cites W2064742171 @default.
• W2008516711 cites W2077752291 @default.
• W2008516711 cites W2081021064 @default.
• W2008516711 cites W2090149382 @default.
• W2008516711 cites W2108935629 @default.
• W2008516711 cites W2134325441 @default.
• W2008516711 cites W2156826712 @default.
• W2008516711 cites W4233500203 @default.
• W2008516711 doi "https://doi.org/10.1016/s0014-5793(99)01364-2" @default.
• W2008516711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10544257" @default.
• W2008516711 hasPublicationYear "1999" @default.
• W2008516711 type Work @default.
• W2008516711 sameAs 2008516711 @default.
• W2008516711 citedByCount "178" @default.
• W2008516711 countsByYear W20085167112012 @default.
• W2008516711 countsByYear W20085167112013 @default.
• W2008516711 countsByYear W20085167112014 @default.
• W2008516711 countsByYear W20085167112015 @default.
• W2008516711 countsByYear W20085167112016 @default.
• W2008516711 countsByYear W20085167112017 @default.
• W2008516711 countsByYear W20085167112018 @default.
• W2008516711 countsByYear W20085167112019 @default.
• W2008516711 countsByYear W20085167112020 @default.
• W2008516711 countsByYear W20085167112023 @default.
• W2008516711 crossrefType "journal-article" @default.
• W2008516711 hasAuthorship W2008516711A5012663065 @default.
• W2008516711 hasAuthorship W2008516711A5014446196 @default.
• W2008516711 hasAuthorship W2008516711A5015580338 @default.
• W2008516711 hasAuthorship W2008516711A5017003826 @default.
• W2008516711 hasAuthorship W2008516711A5059817627 @default.
• W2008516711 hasAuthorship W2008516711A5062146319 @default.
• W2008516711 hasAuthorship W2008516711A5081399911 @default.
• W2008516711 hasAuthorship W2008516711A5083839545 @default.
• W2008516711 hasAuthorship W2008516711A5086761257 @default.
• W2008516711 hasBestOaLocation W20085167111 @default.
• W2008516711 hasConcept C104317684 @default.
• W2008516711 hasConcept C135763542 @default.
• W2008516711 hasConcept C169760540 @default.
• W2008516711 hasConcept C180754005 @default.
• W2008516711 hasConcept C196013638 @default.
• W2008516711 hasConcept C202751555 @default.
• W2008516711 hasConcept C2779547902 @default.
• W2008516711 hasConcept C31467283 @default.
• W2008516711 hasConcept C54355233 @default.
• W2008516711 hasConcept C84597430 @default.
• W2008516711 hasConcept C86745063 @default.
• W2008516711 hasConcept C86803240 @default.
• W2008516711 hasConcept C87644729 @default.
• W2008516711 hasConceptScore W2008516711C104317684 @default.
• W2008516711 hasConceptScore W2008516711C135763542 @default.
• W2008516711 hasConceptScore W2008516711C169760540 @default.
• W2008516711 hasConceptScore W2008516711C180754005 @default.
• W2008516711 hasConceptScore W2008516711C196013638 @default.
• W2008516711 hasConceptScore W2008516711C202751555 @default.
• W2008516711 hasConceptScore W2008516711C2779547902 @default.
• W2008516711 hasConceptScore W2008516711C31467283 @default.
• W2008516711 hasConceptScore W2008516711C54355233 @default.
• W2008516711 hasConceptScore W2008516711C84597430 @default.
• W2008516711 hasConceptScore W2008516711C86745063 @default.
• W2008516711 hasConceptScore W2008516711C86803240 @default.

• next