FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008522087> ?p ?o ?g. }

• W2008522087 endingPage "907" @default.
• W2008522087 startingPage "894" @default.
• W2008522087 abstract "We show that negative-stain electron microscopy and image processing of nucleotide-free (apo) striated muscle myosin-2 subfragment-1 (S1), possessing one light chain or both light chains, is capable of resolving significant amounts of structural detail. The overall appearance of the motor and the lever is similar in rabbit, scallop and chicken S1. Projection matching of class averages of the different S1 types to projection views of two different crystal structures of apo S1 shows that all types most commonly closely resemble the appearance of the scallop S1 structure rather than the methylated chicken S1 structure. Methylation of chicken S1 has no effect on the structure of the molecule at this resolution: it too resembles the scallop S1 crystal structure. The lever is found to vary in its angle of attachment to the motor domain, with a hinge point located in the so-called pliant region between the converter and the essential light chain. The chicken S1 crystal structure lies near one end of the range of flexion observed. The Gaussian spread of angles of flexion suggests that flexibility is driven thermally, from which a torsional spring constant of ~ 23 pN·nm/rad2 is estimated on average for all S1 types, similar to myosin-5. This translates to apparent cantilever-type stiffness at the tip of the lever of 0.37 pN/nm. Because this stiffness is lower than recent estimates from myosin-2 heads attached to actin, we suggest that binding to actin leads to an allosteric stiffening of the motor–lever junction." @default.
• W2008522087 created "2016-06-24" @default.
• W2008522087 creator A5006399271 @default.
• W2008522087 creator A5011563953 @default.
• W2008522087 creator A5073122207 @default.
• W2008522087 creator A5076474690 @default.
• W2008522087 creator A5086287356 @default.
• W2008522087 date "2014-02-01" @default.
• W2008522087 modified "2023-09-27" @default.
• W2008522087 title "Flexibility within the Heads of Muscle Myosin-2 Molecules" @default.
• W2008522087 cites W1482991584 @default.
• W2008522087 cites W1498962226 @default.
• W2008522087 cites W1972130703 @default.
• W2008522087 cites W1977701526 @default.
• W2008522087 cites W1978243335 @default.
• W2008522087 cites W1982554911 @default.
• W2008522087 cites W1983709156 @default.
• W2008522087 cites W1989190442 @default.
• W2008522087 cites W1998192455 @default.
• W2008522087 cites W2002343966 @default.
• W2008522087 cites W2002989090 @default.
• W2008522087 cites W2007096505 @default.
• W2008522087 cites W2008336444 @default.
• W2008522087 cites W2008422555 @default.
• W2008522087 cites W2009985397 @default.
• W2008522087 cites W2012089136 @default.
• W2008522087 cites W2013361751 @default.
• W2008522087 cites W2014719041 @default.
• W2008522087 cites W2018109768 @default.
• W2008522087 cites W2026373135 @default.
• W2008522087 cites W2029851907 @default.
• W2008522087 cites W2036574067 @default.
• W2008522087 cites W2039308541 @default.
• W2008522087 cites W2039542787 @default.
• W2008522087 cites W2043664506 @default.
• W2008522087 cites W2044737423 @default.
• W2008522087 cites W2047608846 @default.
• W2008522087 cites W2048982317 @default.
• W2008522087 cites W2052869024 @default.
• W2008522087 cites W2055876984 @default.
• W2008522087 cites W2057331517 @default.
• W2008522087 cites W2059133459 @default.
• W2008522087 cites W2062142305 @default.
• W2008522087 cites W2064066079 @default.
• W2008522087 cites W2067425020 @default.
• W2008522087 cites W2067592976 @default.
• W2008522087 cites W2069438042 @default.
• W2008522087 cites W2069445258 @default.
• W2008522087 cites W2069953906 @default.
• W2008522087 cites W2077074448 @default.
• W2008522087 cites W2091602849 @default.
• W2008522087 cites W2092954241 @default.
• W2008522087 cites W2098558657 @default.
• W2008522087 cites W2107336909 @default.
• W2008522087 cites W2112590743 @default.
• W2008522087 cites W2123999164 @default.
• W2008522087 cites W2127016760 @default.
• W2008522087 cites W2128739184 @default.
• W2008522087 cites W2131202031 @default.
• W2008522087 cites W2142883438 @default.
• W2008522087 cites W2150913819 @default.
• W2008522087 cites W2153131859 @default.
• W2008522087 cites W2154279541 @default.
• W2008522087 cites W2154663686 @default.
• W2008522087 cites W2156946961 @default.
• W2008522087 cites W2170434548 @default.
• W2008522087 cites W2218720641 @default.
• W2008522087 cites W2220870118 @default.
• W2008522087 cites W4229913877 @default.
• W2008522087 cites W4302343761 @default.
• W2008522087 doi "https://doi.org/10.1016/j.jmb.2013.11.028" @default.
• W2008522087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3919154" @default.
• W2008522087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24333017" @default.
• W2008522087 hasPublicationYear "2014" @default.
• W2008522087 type Work @default.
• W2008522087 sameAs 2008522087 @default.
• W2008522087 citedByCount "24" @default.
• W2008522087 countsByYear W20085220872014 @default.
• W2008522087 countsByYear W20085220872015 @default.
• W2008522087 countsByYear W20085220872016 @default.
• W2008522087 countsByYear W20085220872017 @default.
• W2008522087 countsByYear W20085220872018 @default.
• W2008522087 countsByYear W20085220872019 @default.
• W2008522087 countsByYear W20085220872020 @default.
• W2008522087 countsByYear W20085220872021 @default.
• W2008522087 countsByYear W20085220872022 @default.
• W2008522087 countsByYear W20085220872023 @default.
• W2008522087 crossrefType "journal-article" @default.
• W2008522087 hasAuthorship W2008522087A5006399271 @default.
• W2008522087 hasAuthorship W2008522087A5011563953 @default.
• W2008522087 hasAuthorship W2008522087A5073122207 @default.
• W2008522087 hasAuthorship W2008522087A5076474690 @default.
• W2008522087 hasAuthorship W2008522087A5086287356 @default.
• W2008522087 hasBestOaLocation W20085220871 @default.
• W2008522087 hasConcept C105795698 @default.
• W2008522087 hasConcept C12554922 @default.
• W2008522087 hasConcept C15954220 @default.
• W2008522087 hasConcept C166342909 @default.

• next