FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008522479> ?p ?o ?g. }

• W2008522479 endingPage "5717" @default.
• W2008522479 startingPage "5712" @default.
• W2008522479 abstract "Mammalian Ether-a-go-go related gene (Erg) family voltage-gated K(+) channels possess an unusual gating phenotype that specializes them for a role in delayed repolarization. Mammalian Erg currents rectify during depolarization due to rapid, voltage-dependent inactivation, but rebound during repolarization due to a combination of rapid recovery from inactivation and slow deactivation. This is exemplified by the mammalian Erg1 channel, which is responsible for IKr, a current that repolarizes cardiac action potential plateaus. The Drosophila Erg channel does not inactivate and closes rapidly upon repolarization. The dramatically different properties observed in mammalian and Drosophila Erg homologs bring into question the evolutionary origins of distinct Erg K(+) channel functions. Erg channels are highly conserved in eumetazoans and first evolved in a common ancestor of the placozoans, cnidarians, and bilaterians. To address the ancestral function of Erg channels, we identified and characterized Erg channel paralogs in the sea anemone Nematostella vectensis. N. vectensis Erg1 (NvErg1) is highly conserved with respect to bilaterian homologs and shares the IKr-like gating phenotype with mammalian Erg channels. Thus, the IKr phenotype predates the divergence of cnidarians and bilaterians. NvErg4 and Caenorhabditis elegans Erg (unc-103) share the divergent Drosophila Erg gating phenotype. Phylogenetic and sequence analysis surprisingly indicates that this alternate gating phenotype arose independently in protosomes and cnidarians. Conversion from an ancestral IKr-like gating phenotype to a Drosophila Erg-like phenotype correlates with loss of the cytoplasmic Ether-a-go-go domain. This domain is required for slow deactivation in mammalian Erg1 channels, and thus its loss may partially explain the change in gating phenotype." @default.
• W2008522479 created "2016-06-24" @default.
• W2008522479 creator A5017558968 @default.
• W2008522479 creator A5034766533 @default.
• W2008522479 creator A5036567550 @default.
• W2008522479 creator A5075868548 @default.
• W2008522479 creator A5077641908 @default.
• W2008522479 creator A5082833409 @default.
• W2008522479 creator A5086568453 @default.
• W2008522479 date "2014-03-31" @default.
• W2008522479 modified "2023-09-29" @default.
• W2008522479 title "Functional evolution of Erg potassium channel gating reveals an ancient origin for I _Kr" @default.
• W2008522479 cites W1563302103 @default.
• W2008522479 cites W1630027754 @default.
• W2008522479 cites W1646522829 @default.
• W2008522479 cites W1895029855 @default.
• W2008522479 cites W1925830464 @default.
• W2008522479 cites W1966679178 @default.
• W2008522479 cites W1968098810 @default.
• W2008522479 cites W1970078484 @default.
• W2008522479 cites W1970306779 @default.
• W2008522479 cites W1971421023 @default.
• W2008522479 cites W1984704872 @default.
• W2008522479 cites W2014345338 @default.
• W2008522479 cites W2017641297 @default.
• W2008522479 cites W2021438486 @default.
• W2008522479 cites W2023388715 @default.
• W2008522479 cites W2040826404 @default.
• W2008522479 cites W2041941990 @default.
• W2008522479 cites W2044326283 @default.
• W2008522479 cites W2052976216 @default.
• W2008522479 cites W2053351731 @default.
• W2008522479 cites W2055915652 @default.
• W2008522479 cites W2059957319 @default.
• W2008522479 cites W2066316285 @default.
• W2008522479 cites W2066556072 @default.
• W2008522479 cites W2067558229 @default.
• W2008522479 cites W2090415636 @default.
• W2008522479 cites W2096641211 @default.
• W2008522479 cites W2099762535 @default.
• W2008522479 cites W2107587237 @default.
• W2008522479 cites W2108537834 @default.
• W2008522479 cites W2112621137 @default.
• W2008522479 cites W2117936709 @default.
• W2008522479 cites W2121501171 @default.
• W2008522479 cites W2123976402 @default.
• W2008522479 cites W2129393568 @default.
• W2008522479 cites W2134125338 @default.
• W2008522479 cites W2134462308 @default.
• W2008522479 cites W2141752067 @default.
• W2008522479 cites W2151503690 @default.
• W2008522479 cites W2158714788 @default.
• W2008522479 cites W2168394682 @default.
• W2008522479 cites W2170592109 @default.
• W2008522479 cites W4366065553 @default.
• W2008522479 doi "https://doi.org/10.1073/pnas.1321716111" @default.
• W2008522479 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3992637" @default.
• W2008522479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24706772" @default.
• W2008522479 hasPublicationYear "2014" @default.
• W2008522479 type Work @default.
• W2008522479 sameAs 2008522479 @default.
• W2008522479 citedByCount "42" @default.
• W2008522479 countsByYear W20085224792014 @default.
• W2008522479 countsByYear W20085224792015 @default.
• W2008522479 countsByYear W20085224792016 @default.
• W2008522479 countsByYear W20085224792017 @default.
• W2008522479 countsByYear W20085224792018 @default.
• W2008522479 countsByYear W20085224792019 @default.
• W2008522479 countsByYear W20085224792020 @default.
• W2008522479 countsByYear W20085224792021 @default.
• W2008522479 countsByYear W20085224792022 @default.
• W2008522479 countsByYear W20085224792023 @default.
• W2008522479 crossrefType "journal-article" @default.
• W2008522479 hasAuthorship W2008522479A5017558968 @default.
• W2008522479 hasAuthorship W2008522479A5034766533 @default.
• W2008522479 hasAuthorship W2008522479A5036567550 @default.
• W2008522479 hasAuthorship W2008522479A5075868548 @default.
• W2008522479 hasAuthorship W2008522479A5077641908 @default.
• W2008522479 hasAuthorship W2008522479A5082833409 @default.
• W2008522479 hasAuthorship W2008522479A5086568453 @default.
• W2008522479 hasBestOaLocation W20085224791 @default.
• W2008522479 hasConcept C103796816 @default.
• W2008522479 hasConcept C104317684 @default.
• W2008522479 hasConcept C12554922 @default.
• W2008522479 hasConcept C127716648 @default.
• W2008522479 hasConcept C146403970 @default.
• W2008522479 hasConcept C169760540 @default.
• W2008522479 hasConcept C185263204 @default.
• W2008522479 hasConcept C194544171 @default.
• W2008522479 hasConcept C2777093970 @default.
• W2008522479 hasConcept C54355233 @default.
• W2008522479 hasConcept C78458016 @default.
• W2008522479 hasConcept C86803240 @default.
• W2008522479 hasConcept C95444343 @default.
• W2008522479 hasConceptScore W2008522479C103796816 @default.
• W2008522479 hasConceptScore W2008522479C104317684 @default.
• W2008522479 hasConceptScore W2008522479C12554922 @default.
• W2008522479 hasConceptScore W2008522479C127716648 @default.

• next