Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008542408> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2008542408 endingPage "470" @default.
- W2008542408 startingPage "462" @default.
- W2008542408 abstract "We previously observed that nifedipine reduces aortic hypertrophy in spontaneously hypertensive rats (SHR) partly by inducing smooth muscle cell (SMC) apoptosis. The present study examined nifedipine regulation of SMC apoptosis in carotids with or without a neointima. A neointima was produced by endothelial denudation of the left carotid of SHR and WKY rats. The contralateral carotid remained uninjured. Beginning at week 6 after injury, rats received nifedipine or placebo for 5 and 7 additional weeks. In situ terminal deoxynucleotidyl transferase (TdT)-mediated DNA labeling was used to mark apoptotic nuclei. Nifedipine reduced blood pressure in SHR but not WKY rats. Nifedipine had antihypertrophic effects in both SHR and WKY rats. In each strain, the greater reduction in cross-sectional area was seen in the neointima. In this tissue, nifedipine significantly increased TdT-positive SMC (4-fold at week 5 in SHR and 5-fold at week 7 in WKY rats) and reduced SMC number (70% in SHR and 29% in WKY rats) at week 7 compared to week 0. The effects were less pronounced in the injured and uninjured media. Thus, the antihypertrophic action of nifedipine is amplified in the neointima of SHR and WKY rat carotids, where histological evidence suggests SMC deletion via apoptosis." @default.
- W2008542408 created "2016-06-24" @default.
- W2008542408 creator A5025572908 @default.
- W2008542408 creator A5045726243 @default.
- W2008542408 creator A5059710002 @default.
- W2008542408 creator A5067169596 @default.
- W2008542408 date "2001-01-01" @default.
- W2008542408 modified "2023-09-26" @default.
- W2008542408 title "Regression of Neointimal Lesions in the Carotid Artery of Nifedipine-Treated SHR and WKY Rats: Possible Role of Apoptosis" @default.
- W2008542408 cites W2092405661 @default.
- W2008542408 cites W2114634962 @default.
- W2008542408 cites W2977568416 @default.
- W2008542408 cites W4246301901 @default.
- W2008542408 doi "https://doi.org/10.1159/000051079" @default.
- W2008542408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11561148" @default.
- W2008542408 hasPublicationYear "2001" @default.
- W2008542408 type Work @default.
- W2008542408 sameAs 2008542408 @default.
- W2008542408 citedByCount "22" @default.
- W2008542408 countsByYear W20085424082012 @default.
- W2008542408 countsByYear W20085424082014 @default.
- W2008542408 countsByYear W20085424082018 @default.
- W2008542408 countsByYear W20085424082021 @default.
- W2008542408 countsByYear W20085424082022 @default.
- W2008542408 crossrefType "journal-article" @default.
- W2008542408 hasAuthorship W2008542408A5025572908 @default.
- W2008542408 hasAuthorship W2008542408A5045726243 @default.
- W2008542408 hasAuthorship W2008542408A5059710002 @default.
- W2008542408 hasAuthorship W2008542408A5067169596 @default.
- W2008542408 hasConcept C126322002 @default.
- W2008542408 hasConcept C134018914 @default.
- W2008542408 hasConcept C154113507 @default.
- W2008542408 hasConcept C167414201 @default.
- W2008542408 hasConcept C190283241 @default.
- W2008542408 hasConcept C196795494 @default.
- W2008542408 hasConcept C204232928 @default.
- W2008542408 hasConcept C2777339539 @default.
- W2008542408 hasConcept C2778086073 @default.
- W2008542408 hasConcept C2778283817 @default.
- W2008542408 hasConcept C2778583881 @default.
- W2008542408 hasConcept C2779066535 @default.
- W2008542408 hasConcept C519063684 @default.
- W2008542408 hasConcept C55493867 @default.
- W2008542408 hasConcept C71924100 @default.
- W2008542408 hasConcept C84393581 @default.
- W2008542408 hasConcept C86803240 @default.
- W2008542408 hasConceptScore W2008542408C126322002 @default.
- W2008542408 hasConceptScore W2008542408C134018914 @default.
- W2008542408 hasConceptScore W2008542408C154113507 @default.
- W2008542408 hasConceptScore W2008542408C167414201 @default.
- W2008542408 hasConceptScore W2008542408C190283241 @default.
- W2008542408 hasConceptScore W2008542408C196795494 @default.
- W2008542408 hasConceptScore W2008542408C204232928 @default.
- W2008542408 hasConceptScore W2008542408C2777339539 @default.
- W2008542408 hasConceptScore W2008542408C2778086073 @default.
- W2008542408 hasConceptScore W2008542408C2778283817 @default.
- W2008542408 hasConceptScore W2008542408C2778583881 @default.
- W2008542408 hasConceptScore W2008542408C2779066535 @default.
- W2008542408 hasConceptScore W2008542408C519063684 @default.
- W2008542408 hasConceptScore W2008542408C55493867 @default.
- W2008542408 hasConceptScore W2008542408C71924100 @default.
- W2008542408 hasConceptScore W2008542408C84393581 @default.
- W2008542408 hasConceptScore W2008542408C86803240 @default.
- W2008542408 hasIssue "5" @default.
- W2008542408 hasLocation W20085424081 @default.
- W2008542408 hasLocation W20085424082 @default.
- W2008542408 hasOpenAccess W2008542408 @default.
- W2008542408 hasPrimaryLocation W20085424081 @default.
- W2008542408 hasRelatedWork W1966234050 @default.
- W2008542408 hasRelatedWork W2008542408 @default.
- W2008542408 hasRelatedWork W2171089442 @default.
- W2008542408 hasRelatedWork W2357116242 @default.
- W2008542408 hasRelatedWork W2359081836 @default.
- W2008542408 hasRelatedWork W2381162594 @default.
- W2008542408 hasRelatedWork W2381820491 @default.
- W2008542408 hasRelatedWork W2388367751 @default.
- W2008542408 hasRelatedWork W2391858692 @default.
- W2008542408 hasRelatedWork W788896063 @default.
- W2008542408 hasVolume "38" @default.
- W2008542408 isParatext "false" @default.
- W2008542408 isRetracted "false" @default.
- W2008542408 magId "2008542408" @default.
- W2008542408 workType "article" @default.