FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008544369> ?p ?o ?g. }

• W2008544369 endingPage "e1000451" @default.
• W2008544369 startingPage "e1000451" @default.
• W2008544369 abstract "CLK-2/TEL2 is essential for viability from yeasts to vertebrates, but its essential functions remain ill defined. CLK-2/TEL2 was initially implicated in telomere length regulation in budding yeast, but work in Caenorhabditis elegans has uncovered a function in DNA damage response signalling. Subsequently, DNA damage signalling defects associated with CLK-2/TEL2 have been confirmed in yeast and human cells. The CLK-2/TEL2 interaction with the ATM and ATR DNA damage sensor kinases and its requirement for their stability led to the proposal that CLK-2/TEL2 mutants might phenocopy ATM and/or ATR depletion. We use C. elegans to dissect developmental and cell cycle related roles of CLK-2. Temperature sensitive (ts) clk-2 mutants accumulate genomic instability and show a delay of embryonic cell cycle timing. This delay partially depends on the worm p53 homolog CEP-1 and is rescued by co-depletion of the DNA replication checkpoint proteins ATL-1 (C. elegans ATR) and CHK-1. In addition, clk-2 ts mutants show a spindle orientation defect in the eight cell stages that lead to major cell fate transitions. clk-2 deletion worms progress through embryogenesis and larval development by maternal rescue but become sterile and halt germ cell cycle progression. Unlike ATL-1 depleted germ cells, clk-2–null germ cells do not accumulate DNA double-strand breaks. Rather, clk-2 mutant germ cells arrest with duplicated centrosomes but without mitotic spindles in an early prophase like stage. This germ cell cycle arrest does not depend on cep-1, the DNA replication, or the spindle checkpoint. Our analysis shows that CLK-2 depletion does not phenocopy PIKK kinase depletion. Rather, we implicate CLK-2 in multiple developmental and cell cycle related processes and show that CLK-2 and ATR have antagonising functions during early C. elegans embryonic development." @default.
• W2008544369 created "2016-06-24" @default.
• W2008544369 creator A5007546363 @default.
• W2008544369 creator A5007767008 @default.
• W2008544369 creator A5024718667 @default.
• W2008544369 creator A5046455889 @default.
• W2008544369 creator A5063827776 @default.
• W2008544369 creator A5075785422 @default.
• W2008544369 date "2009-04-10" @default.
• W2008544369 modified "2023-09-26" @default.
• W2008544369 title "Functional Dissection of Caenorhabditis elegans CLK-2/TEL2 Cell Cycle Defects during Embryogenesis and Germline Development" @default.
• W2008544369 cites W1486450190 @default.
• W2008544369 cites W1496559643 @default.
• W2008544369 cites W1549756735 @default.
• W2008544369 cites W1553801822 @default.
• W2008544369 cites W1853857034 @default.
• W2008544369 cites W1863654077 @default.
• W2008544369 cites W1944127002 @default.
• W2008544369 cites W1971850308 @default.
• W2008544369 cites W1986006829 @default.
• W2008544369 cites W1989952069 @default.
• W2008544369 cites W1990119584 @default.
• W2008544369 cites W1999687824 @default.
• W2008544369 cites W2000823493 @default.
• W2008544369 cites W2004963755 @default.
• W2008544369 cites W2005381354 @default.
• W2008544369 cites W2011859278 @default.
• W2008544369 cites W2016495811 @default.
• W2008544369 cites W2019641248 @default.
• W2008544369 cites W2030716239 @default.
• W2008544369 cites W2031805729 @default.
• W2008544369 cites W2035993805 @default.
• W2008544369 cites W2037012605 @default.
• W2008544369 cites W2037239525 @default.
• W2008544369 cites W2037576550 @default.
• W2008544369 cites W2043411667 @default.
• W2008544369 cites W2045201133 @default.
• W2008544369 cites W2048663475 @default.
• W2008544369 cites W2048938594 @default.
• W2008544369 cites W2062601645 @default.
• W2008544369 cites W2071174853 @default.
• W2008544369 cites W2073075035 @default.
• W2008544369 cites W2074651549 @default.
• W2008544369 cites W2076770559 @default.
• W2008544369 cites W2079060327 @default.
• W2008544369 cites W2088197864 @default.
• W2008544369 cites W2096005449 @default.
• W2008544369 cites W2098085839 @default.
• W2008544369 cites W2102566010 @default.
• W2008544369 cites W2102768009 @default.
• W2008544369 cites W2120239133 @default.
• W2008544369 cites W2124384402 @default.
• W2008544369 cites W2124764762 @default.
• W2008544369 cites W2128275272 @default.
• W2008544369 cites W2128491398 @default.
• W2008544369 cites W2129328366 @default.
• W2008544369 cites W2136545880 @default.
• W2008544369 cites W2137249911 @default.
• W2008544369 cites W2142812553 @default.
• W2008544369 cites W2147092039 @default.
• W2008544369 cites W2156430848 @default.
• W2008544369 cites W2165014651 @default.
• W2008544369 cites W2187161614 @default.
• W2008544369 cites W2188677587 @default.
• W2008544369 cites W2189088139 @default.
• W2008544369 cites W2297351368 @default.
• W2008544369 doi "https://doi.org/10.1371/journal.pgen.1000451" @default.
• W2008544369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3101064" @default.
• W2008544369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19360121" @default.
• W2008544369 hasPublicationYear "2009" @default.
• W2008544369 type Work @default.
• W2008544369 sameAs 2008544369 @default.
• W2008544369 citedByCount "40" @default.
• W2008544369 countsByYear W20085443692012 @default.
• W2008544369 countsByYear W20085443692013 @default.
• W2008544369 countsByYear W20085443692014 @default.
• W2008544369 countsByYear W20085443692015 @default.
• W2008544369 countsByYear W20085443692016 @default.
• W2008544369 countsByYear W20085443692017 @default.
• W2008544369 countsByYear W20085443692018 @default.
• W2008544369 countsByYear W20085443692019 @default.
• W2008544369 countsByYear W20085443692020 @default.
• W2008544369 countsByYear W20085443692021 @default.
• W2008544369 countsByYear W20085443692023 @default.
• W2008544369 crossrefType "journal-article" @default.
• W2008544369 hasAuthorship W2008544369A5007546363 @default.
• W2008544369 hasAuthorship W2008544369A5007767008 @default.
• W2008544369 hasAuthorship W2008544369A5024718667 @default.
• W2008544369 hasAuthorship W2008544369A5046455889 @default.
• W2008544369 hasAuthorship W2008544369A5063827776 @default.
• W2008544369 hasAuthorship W2008544369A5075785422 @default.
• W2008544369 hasBestOaLocation W20085443691 @default.
• W2008544369 hasConcept C104317684 @default.
• W2008544369 hasConcept C105696609 @default.
• W2008544369 hasConcept C109825262 @default.
• W2008544369 hasConcept C1491633281 @default.
• W2008544369 hasConcept C2778944004 @default.
• W2008544369 hasConcept C2779122487 @default.

• next