FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008545228> ?p ?o ?g. }

• W2008545228 endingPage "326" @default.
• W2008545228 startingPage "317" @default.
• W2008545228 abstract "To investigate the effects of darifenacin controlled-release (CR) and oxybutynin extended-release (ER) on cognitive function (particularly memory) in older subjects. Healthy subjects (n = 150) ≥60 years were randomised to darifenacin, oxybutynin ER or placebo in a multicentre, double-blind, double-dummy, parallel-group, 3-week study. Doses were administered according to US labels: oxybutynin ER 10 mg once daily (od), increasing to 15 mg od then 20 mg od by week 3; darifenacin 7.5 mg od in weeks 1 and 2, then 15 mg od in week 3. The primary end point was accuracy on the Name–Face Association Test (delayed recall) at week 3. Results of the Name–Face Association Test at week 3 showed no significant difference between darifenacin and placebo on delayed recall (mean difference, −0.06, p = 0.908). In contrast, oxybutynin ER resulted in memory impairment, with significantly lower scores than placebo and darifenacin (mean differences, −1.30, p = 0.011 and −1.24, p = 0.022, respectively) for delayed recall on the Name–Face Association Test at week 3. Additional tests of delayed recall indicated significant memory impairment with oxybutynin ER versus placebo at certain time points, whereas darifenacin was similar to placebo. No between-treatment differences were detected in self-rated memory, demonstrating that subjects were unaware of memory deterioration. While darifenacin had no significant effects on memory versus placebo, oxybutynin ER caused significant memory deterioration (magnitude of effect comparable to brain aging of 10 years). The results also demonstrate that subjects may not recognise/report memory deterioration." @default.
• W2008545228 created "2016-06-24" @default.
• W2008545228 creator A5000740098 @default.
• W2008545228 creator A5006698422 @default.
• W2008545228 creator A5023274006 @default.
• W2008545228 creator A5039886247 @default.
• W2008545228 creator A5040137306 @default.
• W2008545228 creator A5057290256 @default.
• W2008545228 creator A5061313248 @default.
• W2008545228 date "2006-08-01" @default.
• W2008545228 modified "2023-10-09" @default.
• W2008545228 title "Differential Effects of the Antimuscarinic Agents Darifenacin and Oxybutynin ER on Memory in Older Subjects" @default.
• W2008545228 cites W1596886387 @default.
• W2008545228 cites W1965868118 @default.
• W2008545228 cites W1966898312 @default.
• W2008545228 cites W1972740319 @default.
• W2008545228 cites W1977456202 @default.
• W2008545228 cites W1986115550 @default.
• W2008545228 cites W1991693093 @default.
• W2008545228 cites W2006909079 @default.
• W2008545228 cites W2016231653 @default.
• W2008545228 cites W2025896506 @default.
• W2008545228 cites W2026648962 @default.
• W2008545228 cites W2030052255 @default.
• W2008545228 cites W2033133691 @default.
• W2008545228 cites W2037651109 @default.
• W2008545228 cites W2039398668 @default.
• W2008545228 cites W2057928770 @default.
• W2008545228 cites W2063975302 @default.
• W2008545228 cites W2072160092 @default.
• W2008545228 cites W2089864602 @default.
• W2008545228 cites W2090257820 @default.
• W2008545228 cites W2113453644 @default.
• W2008545228 cites W2131921904 @default.
• W2008545228 cites W2134928141 @default.
• W2008545228 cites W4238359599 @default.
• W2008545228 cites W4251446496 @default.
• W2008545228 cites W4254369195 @default.
• W2008545228 doi "https://doi.org/10.1016/j.eururo.2006.03.057" @default.
• W2008545228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16687205" @default.
• W2008545228 hasPublicationYear "2006" @default.
• W2008545228 type Work @default.
• W2008545228 sameAs 2008545228 @default.
• W2008545228 citedByCount "263" @default.
• W2008545228 countsByYear W20085452282012 @default.
• W2008545228 countsByYear W20085452282013 @default.
• W2008545228 countsByYear W20085452282014 @default.
• W2008545228 countsByYear W20085452282015 @default.
• W2008545228 countsByYear W20085452282016 @default.
• W2008545228 countsByYear W20085452282017 @default.
• W2008545228 countsByYear W20085452282018 @default.
• W2008545228 countsByYear W20085452282019 @default.
• W2008545228 countsByYear W20085452282020 @default.
• W2008545228 countsByYear W20085452282021 @default.
• W2008545228 countsByYear W20085452282022 @default.
• W2008545228 countsByYear W20085452282023 @default.
• W2008545228 crossrefType "journal-article" @default.
• W2008545228 hasAuthorship W2008545228A5000740098 @default.
• W2008545228 hasAuthorship W2008545228A5006698422 @default.
• W2008545228 hasAuthorship W2008545228A5023274006 @default.
• W2008545228 hasAuthorship W2008545228A5039886247 @default.
• W2008545228 hasAuthorship W2008545228A5040137306 @default.
• W2008545228 hasAuthorship W2008545228A5057290256 @default.
• W2008545228 hasAuthorship W2008545228A5061313248 @default.
• W2008545228 hasConcept C126894567 @default.
• W2008545228 hasConcept C142724271 @default.
• W2008545228 hasConcept C204787440 @default.
• W2008545228 hasConcept C27081682 @default.
• W2008545228 hasConcept C2777844464 @default.
• W2008545228 hasConcept C2778941218 @default.
• W2008545228 hasConcept C42219234 @default.
• W2008545228 hasConcept C71924100 @default.
• W2008545228 hasConceptScore W2008545228C126894567 @default.
• W2008545228 hasConceptScore W2008545228C142724271 @default.
• W2008545228 hasConceptScore W2008545228C204787440 @default.
• W2008545228 hasConceptScore W2008545228C27081682 @default.
• W2008545228 hasConceptScore W2008545228C2777844464 @default.
• W2008545228 hasConceptScore W2008545228C2778941218 @default.
• W2008545228 hasConceptScore W2008545228C42219234 @default.
• W2008545228 hasConceptScore W2008545228C71924100 @default.
• W2008545228 hasIssue "2" @default.
• W2008545228 hasLocation W20085452281 @default.
• W2008545228 hasLocation W20085452282 @default.
• W2008545228 hasOpenAccess W2008545228 @default.
• W2008545228 hasPrimaryLocation W20085452281 @default.
• W2008545228 hasRelatedWork W138736198 @default.
• W2008545228 hasRelatedWork W1821426726 @default.
• W2008545228 hasRelatedWork W1972451622 @default.
• W2008545228 hasRelatedWork W1996684801 @default.
• W2008545228 hasRelatedWork W2020594337 @default.
• W2008545228 hasRelatedWork W2028811068 @default.
• W2008545228 hasRelatedWork W2111574840 @default.
• W2008545228 hasRelatedWork W2141823090 @default.
• W2008545228 hasRelatedWork W2339866418 @default.
• W2008545228 hasRelatedWork W4233016836 @default.
• W2008545228 hasVolume "50" @default.
• W2008545228 isParatext "false" @default.
• W2008545228 isRetracted "false" @default.

• next