FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008546158> ?p ?o ?g. }

• W2008546158 endingPage "7565" @default.
• W2008546158 startingPage "7561" @default.
• W2008546158 abstract "The Global Polio Eradication Initiative, established in 1988, has made substantial progress toward achieving this target, with only 3 countries never having eliminated wild poliovirus. Persons with primary immune deficiency disorders (PIDD) exposed to OPV are at increased risk of vaccine-associated paralytic poliomyelitis (VAPP) and of prolonged excretion of Sabin polioviruses. However, the risk for prolonged excretion is not known. Therefore, we studied the prevalence of PIDD with long-term poliovirus excretion in Sri Lanka, a middle income country currently using OPV. We stimulated the referral of patients under the age of 35 years, with clinical features suggestive of immune deficiency to the single immunology clinic in the country, where these patients were investigated for the presence of PIDD. Stool samples from patients with PIDD were cultured for the presence of poliovirus (PV). Poliovirus isolates were tested for intratypic differentiation (ITD). The VP1 region of all poliovirus isolates was sequenced. Of 942 patients investigated, 51 (5.4%) were diagnosed with PIDD. Five (10.2%) patients excreted poliovirus. A patient with X linked agammaglobulinemia (XLA) excreted a mixture of all three Sabin like (SL) poliovirus serotypes. One patient with severe combined immune deficiency (SCID) excreted SL type 2, and another with SCID excreted SL type 3. One patient with SCID excreted a P2 vaccine-derived poliovirus (VDPV 2), and another with common variable immune deficiency (CVID) excreted a VDPV 3. The 3 patients with SCID died before scheduled collection of subsequent samples one month later, while the patient with XLA had cleared the virus in stool sample collected after 3 and 11 months. The CVID patient with VDPV 3 excreted for 7 months, and has developed a 23 nucleotide divergence in VP1 (∼900 nucleotides) from the parental Sabin virus. In our study, several patients with SCID, XLA and CVID excreted poliovirus. With improving health care quality patients with CVID and XLA may survive longer especially with provision of intravenous immune globulin. Regular screening of patients with PIDD for excretion of poliovirus is necessary to identify chronic excretors and make available specific therapies." @default.
• W2008546158 created "2016-06-24" @default.
• W2008546158 creator A5013556034 @default.
• W2008546158 creator A5015341323 @default.
• W2008546158 creator A5021776381 @default.
• W2008546158 creator A5029393625 @default.
• W2008546158 creator A5036590679 @default.
• W2008546158 creator A5037477467 @default.
• W2008546158 creator A5052463454 @default.
• W2008546158 creator A5059094423 @default.
• W2008546158 creator A5089815182 @default.
• W2008546158 date "2012-12-01" @default.
• W2008546158 modified "2023-09-27" @default.
• W2008546158 title "Prevalence of prolonged and chronic poliovirus excretion among persons with primary immune deficiency disorders in Sri Lanka" @default.
• W2008546158 cites W1973936744 @default.
• W2008546158 cites W1981598477 @default.
• W2008546158 cites W1985800217 @default.
• W2008546158 cites W2000937204 @default.
• W2008546158 cites W2012670542 @default.
• W2008546158 cites W2022472533 @default.
• W2008546158 cites W2029734203 @default.
• W2008546158 cites W2035273854 @default.
• W2008546158 cites W2041302422 @default.
• W2008546158 cites W2089996985 @default.
• W2008546158 cites W2101462714 @default.
• W2008546158 cites W2105733675 @default.
• W2008546158 cites W2114918609 @default.
• W2008546158 cites W2117691753 @default.
• W2008546158 cites W2132936904 @default.
• W2008546158 cites W2134453112 @default.
• W2008546158 cites W2146139689 @default.
• W2008546158 cites W2159041114 @default.
• W2008546158 cites W2169709492 @default.
• W2008546158 cites W4245154879 @default.
• W2008546158 doi "https://doi.org/10.1016/j.vaccine.2012.10.035" @default.
• W2008546158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23099333" @default.
• W2008546158 hasPublicationYear "2012" @default.
• W2008546158 type Work @default.
• W2008546158 sameAs 2008546158 @default.
• W2008546158 citedByCount "31" @default.
• W2008546158 countsByYear W20085461582013 @default.
• W2008546158 countsByYear W20085461582014 @default.
• W2008546158 countsByYear W20085461582015 @default.
• W2008546158 countsByYear W20085461582016 @default.
• W2008546158 countsByYear W20085461582017 @default.
• W2008546158 countsByYear W20085461582018 @default.
• W2008546158 countsByYear W20085461582019 @default.
• W2008546158 countsByYear W20085461582020 @default.
• W2008546158 crossrefType "journal-article" @default.
• W2008546158 hasAuthorship W2008546158A5013556034 @default.
• W2008546158 hasAuthorship W2008546158A5015341323 @default.
• W2008546158 hasAuthorship W2008546158A5021776381 @default.
• W2008546158 hasAuthorship W2008546158A5029393625 @default.
• W2008546158 hasAuthorship W2008546158A5036590679 @default.
• W2008546158 hasAuthorship W2008546158A5037477467 @default.
• W2008546158 hasAuthorship W2008546158A5052463454 @default.
• W2008546158 hasAuthorship W2008546158A5059094423 @default.
• W2008546158 hasAuthorship W2008546158A5089815182 @default.
• W2008546158 hasConcept C10146269 @default.
• W2008546158 hasConcept C10389963 @default.
• W2008546158 hasConcept C126322002 @default.
• W2008546158 hasConcept C159047783 @default.
• W2008546158 hasConcept C159654299 @default.
• W2008546158 hasConcept C170493617 @default.
• W2008546158 hasConcept C187212893 @default.
• W2008546158 hasConcept C203014093 @default.
• W2008546158 hasConcept C2522874641 @default.
• W2008546158 hasConcept C2776433325 @default.
• W2008546158 hasConcept C2779528874 @default.
• W2008546158 hasConcept C2779631682 @default.
• W2008546158 hasConcept C42362537 @default.
• W2008546158 hasConcept C4870876 @default.
• W2008546158 hasConcept C71924100 @default.
• W2008546158 hasConcept C8891405 @default.
• W2008546158 hasConcept C90059517 @default.
• W2008546158 hasConceptScore W2008546158C10146269 @default.
• W2008546158 hasConceptScore W2008546158C10389963 @default.
• W2008546158 hasConceptScore W2008546158C126322002 @default.
• W2008546158 hasConceptScore W2008546158C159047783 @default.
• W2008546158 hasConceptScore W2008546158C159654299 @default.
• W2008546158 hasConceptScore W2008546158C170493617 @default.
• W2008546158 hasConceptScore W2008546158C187212893 @default.
• W2008546158 hasConceptScore W2008546158C203014093 @default.
• W2008546158 hasConceptScore W2008546158C2522874641 @default.
• W2008546158 hasConceptScore W2008546158C2776433325 @default.
• W2008546158 hasConceptScore W2008546158C2779528874 @default.
• W2008546158 hasConceptScore W2008546158C2779631682 @default.
• W2008546158 hasConceptScore W2008546158C42362537 @default.
• W2008546158 hasConceptScore W2008546158C4870876 @default.
• W2008546158 hasConceptScore W2008546158C71924100 @default.
• W2008546158 hasConceptScore W2008546158C8891405 @default.
• W2008546158 hasConceptScore W2008546158C90059517 @default.
• W2008546158 hasFunder F4320307856 @default.
• W2008546158 hasIssue "52" @default.
• W2008546158 hasLocation W20085461581 @default.
• W2008546158 hasLocation W20085461582 @default.
• W2008546158 hasOpenAccess W2008546158 @default.
• W2008546158 hasPrimaryLocation W20085461581 @default.

• next