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- W2008546357 abstract "The objective of this paper is to synthesise extant studies describing the neurotherapeutic effects of antidiabetic agents in neuropsychiatric disorders. The authors conducted a MedLine search of all English-language articles published between 1966 and March 2006. The search terms were the nonproprietary names of established and putative antidiabetic agents (e.g., insulin, insulin secretagogues and sensitisers) cross-referenced with the individual names of Diagnostic and Statistical Manual of Mental Disorders (DSM)-III-R/IV/-TR-defined mood, psychotic, anxiety and dementing disorders. The search was augmented with a manual review of article reference lists. Contemporary models of disease pathophysiology in major depressive disorder, bipolar disorder and several dementing disorders (e.g., Alzheimer’s disease) emphasise alterations in cellular plasticity and cytoarchitecture, with associated regional abnormalities in neuronal and glial density and morphology. Antidiabetic treatments (e.g., thiazolidinediones) may be capable of attenuating this pathological process via disparate mechanisms (e.g., neuroprotective, neurotrophic, anti-inflammatory). Enhanced insulin signalling with antidiabetic treatments may preserve and/or augment cognitive function in several neuropsychiatric disorders. Antidiabetic treatments, which maintain euglycaemia, hold promise as potent and clinically significant therapeutic interventions for several neuropsychiatric disorders." @default.
- W2008546357 created "2016-06-24" @default.
- W2008546357 creator A5013738913 @default.
- W2008546357 creator A5017050709 @default.
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- W2008546357 creator A5032497184 @default.
- W2008546357 creator A5034414826 @default.
- W2008546357 creator A5068850044 @default.
- W2008546357 date "2006-06-29" @default.
- W2008546357 modified "2023-10-03" @default.
- W2008546357 title "Managing psychiatric disorders with antidiabetic agents: translational research and treatment opportunities" @default.
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