Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008552722> ?p ?o ?g. }
- W2008552722 endingPage "30940" @default.
- W2008552722 startingPage "30933" @default.
- W2008552722 abstract "Loss of CDKN2A/p16(INK4A) in hematopoietic stem cells is associated with enhanced self-renewal capacity and might facilitate progression of damaged stem cells into pre-cancerous cells that give rise to leukemia. This is also reflected by the frequent loss of the INK4A locus in acute lymphoblastic T-cell leukemia. T-cell acute lymphoblastic leukemia cells designed to conditionally express p16(INK4A) arrest in the G(0)/G(1) phase of the cell cycle and show increased sensitivity to glucocorticoid- and tumor necrosis factor receptor superfamily 6-induced apoptosis. To investigate the underlying molecular mechanism for increased death sensitivity, we interfered with specific steps of apoptosis signaling by expression of anti-apoptotic proteins. We found that alterations in cell death susceptibility resulted from changes in the composition of pro- and anti-apoptotic BCL2 proteins, i.e. repression of MCL1, BCL2, and PMAIP1/Noxa and the induction of pro-apoptotic BBC3/Puma. Interference with Puma induction by short hairpin RNA technology or retroviral expression of MCL1 or BCL2 significantly reduced both glucocorticoid- and FAS-induced cell death in p16(INK4A)-reconstituted leukemia cells. These results suggest that Puma, in concert with MCL1 and BCL2 repression, critically mediates p16(INK4A)-induced death sensitization and that in human T-cell leukemia the deletion of p16(INK4A) confers apoptosis resistance by shifting the balance of pro- and anti-apoptotic BCL2 proteins toward apoptosis protection." @default.
- W2008552722 created "2016-06-24" @default.
- W2008552722 creator A5001095928 @default.
- W2008552722 creator A5007135836 @default.
- W2008552722 creator A5009512871 @default.
- W2008552722 creator A5024378899 @default.
- W2008552722 creator A5041108174 @default.
- W2008552722 creator A5045142417 @default.
- W2008552722 creator A5055627222 @default.
- W2008552722 creator A5063354100 @default.
- W2008552722 creator A5078954786 @default.
- W2008552722 creator A5082440581 @default.
- W2008552722 date "2009-11-01" @default.
- W2008552722 modified "2023-10-06" @default.
- W2008552722 title "p16 Sensitizes Human Leukemia Cells to FAS- and Glucocorticoid-induced Apoptosis via Induction of BBC3/Puma and Repression of MCL1 and BCL2" @default.
- W2008552722 cites W1593219141 @default.
- W2008552722 cites W169454248 @default.
- W2008552722 cites W1964677287 @default.
- W2008552722 cites W1968796569 @default.
- W2008552722 cites W1971079672 @default.
- W2008552722 cites W1973109581 @default.
- W2008552722 cites W1978554125 @default.
- W2008552722 cites W1979129905 @default.
- W2008552722 cites W1982186179 @default.
- W2008552722 cites W1984705562 @default.
- W2008552722 cites W1997069623 @default.
- W2008552722 cites W1998492363 @default.
- W2008552722 cites W2007057690 @default.
- W2008552722 cites W2008376982 @default.
- W2008552722 cites W2008715871 @default.
- W2008552722 cites W2008841394 @default.
- W2008552722 cites W2015680924 @default.
- W2008552722 cites W2018017071 @default.
- W2008552722 cites W2042850275 @default.
- W2008552722 cites W2046714061 @default.
- W2008552722 cites W2062440161 @default.
- W2008552722 cites W2066848701 @default.
- W2008552722 cites W2071909988 @default.
- W2008552722 cites W2075400389 @default.
- W2008552722 cites W2084891010 @default.
- W2008552722 cites W2089082314 @default.
- W2008552722 cites W2097844867 @default.
- W2008552722 cites W2102597691 @default.
- W2008552722 cites W2112968535 @default.
- W2008552722 cites W2121619780 @default.
- W2008552722 cites W2147318282 @default.
- W2008552722 cites W2151414819 @default.
- W2008552722 cites W2160088989 @default.
- W2008552722 cites W2328813921 @default.
- W2008552722 cites W2409731915 @default.
- W2008552722 cites W4237567990 @default.
- W2008552722 cites W85340634 @default.
- W2008552722 doi "https://doi.org/10.1074/jbc.m109.051441" @default.
- W2008552722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2781493" @default.
- W2008552722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19737931" @default.
- W2008552722 hasPublicationYear "2009" @default.
- W2008552722 type Work @default.
- W2008552722 sameAs 2008552722 @default.
- W2008552722 citedByCount "18" @default.
- W2008552722 countsByYear W20085527222012 @default.
- W2008552722 countsByYear W20085527222013 @default.
- W2008552722 countsByYear W20085527222014 @default.
- W2008552722 countsByYear W20085527222016 @default.
- W2008552722 countsByYear W20085527222017 @default.
- W2008552722 countsByYear W20085527222020 @default.
- W2008552722 countsByYear W20085527222021 @default.
- W2008552722 crossrefType "journal-article" @default.
- W2008552722 hasAuthorship W2008552722A5001095928 @default.
- W2008552722 hasAuthorship W2008552722A5007135836 @default.
- W2008552722 hasAuthorship W2008552722A5009512871 @default.
- W2008552722 hasAuthorship W2008552722A5024378899 @default.
- W2008552722 hasAuthorship W2008552722A5041108174 @default.
- W2008552722 hasAuthorship W2008552722A5045142417 @default.
- W2008552722 hasAuthorship W2008552722A5055627222 @default.
- W2008552722 hasAuthorship W2008552722A5063354100 @default.
- W2008552722 hasAuthorship W2008552722A5078954786 @default.
- W2008552722 hasAuthorship W2008552722A5082440581 @default.
- W2008552722 hasBestOaLocation W20085527221 @default.
- W2008552722 hasConcept C104317684 @default.
- W2008552722 hasConcept C109159458 @default.
- W2008552722 hasConcept C127561419 @default.
- W2008552722 hasConcept C179464577 @default.
- W2008552722 hasConcept C190283241 @default.
- W2008552722 hasConcept C203014093 @default.
- W2008552722 hasConcept C2776090121 @default.
- W2008552722 hasConcept C2777417711 @default.
- W2008552722 hasConcept C2778461978 @default.
- W2008552722 hasConcept C2779176958 @default.
- W2008552722 hasConcept C28328180 @default.
- W2008552722 hasConcept C31573885 @default.
- W2008552722 hasConcept C502942594 @default.
- W2008552722 hasConcept C54355233 @default.
- W2008552722 hasConcept C56483683 @default.
- W2008552722 hasConcept C86803240 @default.
- W2008552722 hasConcept C8891405 @default.
- W2008552722 hasConcept C95444343 @default.
- W2008552722 hasConcept C98424977 @default.
- W2008552722 hasConceptScore W2008552722C104317684 @default.