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- W2008558476 abstract "Primer extension arrest (PEA) studies have demonstrated that antisense oligonucleotides (beta 112C, beta 114C), which lie upstream of a ribozyme targeted to beta-amyloid peptide precursor (beta APP) mRNA, but not sense oligonucleotides (beta 112S, beta 116S) or a scrambled oligonucleotide, beta 116 M, affect ribozyme-mediated cleavage in vitro. Substrate dissociation experiments revealed that the ribozyme binding site in this mRNA was masked; PEA kinetics showed the association of the ribozyme and substrate was enhanced by antisense oligonucleotide binding. These studies suggest that masked ribozyme cleavage sites that may occur in disease-causing mRNAs can be targeted for degradation using facilitator oligonucleotides." @default.
- W2008558476 created "2016-06-24" @default.
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- W2008558476 date "1996-03-11" @default.
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- W2008558476 title "Facilitator oligonucleotides increase ribozyme RNA binding to full-length RNA substrates in vitro" @default.
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- W2008558476 doi "https://doi.org/10.1016/0014-5793(96)00125-1" @default.
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