FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008564665> ?p ?o ?g. }

• W2008564665 endingPage "2093" @default.
• W2008564665 startingPage "2081" @default.
• W2008564665 abstract "By use of a parallel and partly crossover randomised, controlled trial design we sought to elucidate the underlying mechanisms behind the advantageous effects of interval walking training (IWT) compared with continuous walking training (CWT) on glycaemic control in individuals with type 2 diabetes. We hypothesised that IWT, more than CWT, would improve insulin sensitivity including skeletal muscle insulin signalling, insulin secretion and disposition index (DI).By simple randomisation (sequentially numbered, opaque sealed envelopes), eligible individuals (diagnosed with type 2 diabetes, no exogenous insulin treatment) were allocated to three groups: a control group (CON, n = 8), an IWT group (n = 12) and an energy expenditure-matched CWT group (n = 12). Training groups were prescribed free-living training, five sessions per week (60 min/session). A three-stage hyperglycaemic clamp, including glucose isotope tracers and skeletal muscle biopsies, was performed before and after a 4 month intervention in a hospitalised setting. No blinding was performed.The improved glycaemic control, which was only seen in the IWT group, was consistent with IWT-induced increases in insulin sensitivity index (49.8 ± 14.6%; p < 0.001), peripheral glucose disposal (14.5 ± 4.9%; p < 0.05) and DI (66.2 ± 21.8%; p < 0.001), with no changes in the CWT or CON group. Moreover, only IWT improved insulin signalling in skeletal muscle via increased insulin-stimulated phosphorylation of AS160 (29.0 ± 10.8%; p < 0.05). No changes were seen in insulin secretion during hyperglycaemia alone, hyperglycaemia + glucagon-like peptide 1 infusion or arginine injection.IWT maintains insulin secretion and improves insulin sensitivity and DI, in contrast to energy expenditure-matched CWT. These results suggest that training with alternating intensity, and not just training volume and mean intensity, is a key determinant of changes in whole body glucose disposal in individuals with type 2 diabetes.ClinicalTrials (NCT01234155)." @default.
• W2008564665 created "2016-06-24" @default.
• W2008564665 creator A5015937337 @default.
• W2008564665 creator A5019935567 @default.
• W2008564665 creator A5020198417 @default.
• W2008564665 creator A5051857476 @default.
• W2008564665 creator A5057969496 @default.
• W2008564665 creator A5059817069 @default.
• W2008564665 creator A5060815860 @default.
• W2008564665 creator A5065850266 @default.
• W2008564665 creator A5072290749 @default.
• W2008564665 date "2014-08-07" @default.
• W2008564665 modified "2023-10-07" @default.
• W2008564665 title "Mechanisms behind the superior effects of interval vs continuous training on glycaemic control in individuals with type 2 diabetes: a randomised controlled trial" @default.
• W2008564665 cites W1851758680 @default.
• W2008564665 cites W1966012125 @default.
• W2008564665 cites W1968826789 @default.
• W2008564665 cites W1969171226 @default.
• W2008564665 cites W1970894916 @default.
• W2008564665 cites W1987588766 @default.
• W2008564665 cites W1991060376 @default.
• W2008564665 cites W2007775784 @default.
• W2008564665 cites W2010367429 @default.
• W2008564665 cites W2010763118 @default.
• W2008564665 cites W2016732441 @default.
• W2008564665 cites W2018459966 @default.
• W2008564665 cites W2024175757 @default.
• W2008564665 cites W2024323540 @default.
• W2008564665 cites W2027219674 @default.
• W2008564665 cites W2043791247 @default.
• W2008564665 cites W2047243213 @default.
• W2008564665 cites W2048488935 @default.
• W2008564665 cites W2051066158 @default.
• W2008564665 cites W2061450364 @default.
• W2008564665 cites W2062699052 @default.
• W2008564665 cites W2066591034 @default.
• W2008564665 cites W2084643101 @default.
• W2008564665 cites W2087018063 @default.
• W2008564665 cites W2103699188 @default.
• W2008564665 cites W2108683990 @default.
• W2008564665 cites W2115702661 @default.
• W2008564665 cites W2117233341 @default.
• W2008564665 cites W2118261488 @default.
• W2008564665 cites W2133576538 @default.
• W2008564665 cites W2136896338 @default.
• W2008564665 cites W2137206121 @default.
• W2008564665 cites W2141158637 @default.
• W2008564665 cites W2141295252 @default.
• W2008564665 cites W2142369185 @default.
• W2008564665 cites W2143269619 @default.
• W2008564665 cites W2144417251 @default.
• W2008564665 cites W2144651037 @default.
• W2008564665 cites W2146480641 @default.
• W2008564665 cites W2158620938 @default.
• W2008564665 cites W2163870475 @default.
• W2008564665 cites W2166073051 @default.
• W2008564665 cites W2167485048 @default.
• W2008564665 cites W2267618570 @default.
• W2008564665 cites W2321947552 @default.
• W2008564665 cites W2416937488 @default.
• W2008564665 cites W3171237122 @default.
• W2008564665 cites W4255692377 @default.
• W2008564665 doi "https://doi.org/10.1007/s00125-014-3334-5" @default.
• W2008564665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25099941" @default.
• W2008564665 hasPublicationYear "2014" @default.
• W2008564665 type Work @default.
• W2008564665 sameAs 2008564665 @default.
• W2008564665 citedByCount "66" @default.
• W2008564665 countsByYear W20085646652015 @default.
• W2008564665 countsByYear W20085646652016 @default.
• W2008564665 countsByYear W20085646652017 @default.
• W2008564665 countsByYear W20085646652018 @default.
• W2008564665 countsByYear W20085646652019 @default.
• W2008564665 countsByYear W20085646652020 @default.
• W2008564665 countsByYear W20085646652021 @default.
• W2008564665 countsByYear W20085646652022 @default.
• W2008564665 countsByYear W20085646652023 @default.
• W2008564665 crossrefType "journal-article" @default.
• W2008564665 hasAuthorship W2008564665A5015937337 @default.
• W2008564665 hasAuthorship W2008564665A5019935567 @default.
• W2008564665 hasAuthorship W2008564665A5020198417 @default.
• W2008564665 hasAuthorship W2008564665A5051857476 @default.
• W2008564665 hasAuthorship W2008564665A5057969496 @default.
• W2008564665 hasAuthorship W2008564665A5059817069 @default.
• W2008564665 hasAuthorship W2008564665A5060815860 @default.
• W2008564665 hasAuthorship W2008564665A5065850266 @default.
• W2008564665 hasAuthorship W2008564665A5072290749 @default.
• W2008564665 hasBestOaLocation W20085646651 @default.
• W2008564665 hasConcept C126322002 @default.
• W2008564665 hasConcept C134018914 @default.
• W2008564665 hasConcept C142724271 @default.
• W2008564665 hasConcept C168563851 @default.
• W2008564665 hasConcept C204787440 @default.
• W2008564665 hasConcept C27081682 @default.
• W2008564665 hasConcept C2771230 @default.
• W2008564665 hasConcept C2777180221 @default.
• W2008564665 hasConcept C2777391703 @default.
• W2008564665 hasConcept C2777973682 @default.

• next