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- W2008565556 abstract "L'intoxication digitalique chez l'enfant est le plus souvent d'origine accidentelle. Nous rapportons une observation chez un jeune nourrisson porteur d'une cardiopathie congénitale, où la coadministration de digoxine et josamycine a augmenté de 50 % la digoxinémie, provoqué un bloc sinoauriculaire et occasionné une décompensation cardiaque. Les manifestations cliniques et électrocardiographiques ont rétrocédé très rapidement après immunothérapie spécifique par fragments Fab antidigitaliques. Ce fait clinique plaide pour une surveillance attentive des concentrations de digoxine au cours d'une antibiothérapie par macrolides chez l'enfant, les doses de digoxine pouvant nécessiter un réajustement. Digitalis intoxication is usually accidental in children. We report the case of a young infant with congenital heart disease in whom the coadministration of digoxin and josamycin led to a 50% increase in the digoxin concentration, generating sinoatrial block and cardiac failure. Clinical and electrocardiographic symptoms very quickly resolved following immunotherapy with antidigitalis Fab fragments. Digoxin concentrations must be carefully monitored in patients concomitantly receiving macrolides to ensure that the digoxin dose can be readjusted if necessary." @default.
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- W2008565556 date "2006-08-01" @default.
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- W2008565556 title "Digoxine-Josamycine : une interaction dangereuse chez l'enfant" @default.
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- W2008565556 doi "https://doi.org/10.1016/j.arcped.2006.04.021" @default.
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