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• W2008570998 abstract "Cancer cells migrating within a 3D microenvironment are able to adopt either a mesenchymal or amoeboid mode of migration. Amoeboid migration is characterised by membrane blebbing that is dependent on the Rho effectors, ROCK1/2. We identify LIMK2 as the preferred substrate for ROCK1 but find that LIMK2 did not induce membrane blebbing, suggesting that a LIMK2 pathway is not involved in amoeboid-mode migration. In support of this hypothesis, novel FRET data demonstrate a direct interaction between ROCK1 and LIMK2 in polarised but not blebbing cells. Our results point to a specific role for the ROCK1:LIMK2 pathway in mesenchymal-mode migration." @default.
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• W2008570998 date "2008-10-14" @default.
• W2008570998 modified "2023-10-18" @default.
• W2008570998 title "ROCK1 and LIMK2 Interact in Spread but Not Blebbing Cancer Cells" @default.
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• W2008570998 doi "https://doi.org/10.1371/journal.pone.0003398" @default.
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