FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008576446> ?p ?o ?g. }

• W2008576446 endingPage "1338" @default.
• W2008576446 startingPage "1328" @default.
• W2008576446 abstract "Abstract BACKGROUND The major cause of death in prostate cancer (PCa) cases is due to distant metastatic lesions, with the bone being the most prevalent site for secondary colonization. Utilization of small molecule inhibitors to treat bone metastatic PCa have had limited success either as monotherapies or in combination with other chemotherapeutics due to intolerable toxicities. In the current study, we developed a clinically relevant in vivo intraosseous tumor model overexpressing the platelet‐derived growth factor D (PDGF D) to test the efficacy of a newly characterized vascular endothelial growth factor receptor (VEGFR)/PDGFR inhibitor, cediranib (also called AZD2171). METHODS An intratibial‐injection model was established utilizing DU145 cells with or without increased PDGF D expression. Tumor‐bearing mice were treated by daily gavage administration of cediranib and/or weekly i.p. injection of docetaxel for 7 weeks. Tibiae were monitored by in vivo/ex vivo X‐rays and histomorphometry analysis was performed to estimate tumor volume and tumor‐associated trabecular bone growth. RESULTS Cediranib reduced intraosseous growth of prostate tumors as well as tumor‐associated bone responses. When compared to the standard chemotherapeutic agent docetaxel, cediranib exhibited a stronger inhibition of tumor‐associated bone response. The efficacy of cediranib was further enhanced when the drug was co‐administered with docetaxel. Importantly, the therapeutic benefits of cediranib and docetaxel are more prominent in intraosseous prostate tumors overexpressing PDGF D. CONCLUSION These novel findings support the utilization of cediranib, either alone or in combination with docetaxel, to treat bone metastatic PCa exhibiting PDGF D expression. Prostate 72:1328–1338, 2012. © 2011 Wiley Periodicals, Inc." @default.
• W2008576446 created "2016-06-24" @default.
• W2008576446 creator A5000198604 @default.
• W2008576446 creator A5012197303 @default.
• W2008576446 creator A5016182502 @default.
• W2008576446 creator A5016334197 @default.
• W2008576446 creator A5035773159 @default.
• W2008576446 creator A5037867453 @default.
• W2008576446 creator A5043787548 @default.
• W2008576446 creator A5049134760 @default.
• W2008576446 creator A5053941488 @default.
• W2008576446 creator A5054035098 @default.
• W2008576446 date "2011-12-27" @default.
• W2008576446 modified "2023-10-10" @default.
• W2008576446 title "Cediranib inhibits both the intraosseous growth of PDGF D-Positive prostate cancer cells and the associated bone reaction" @default.
• W2008576446 cites W1583970297 @default.
• W2008576446 cites W1587419561 @default.
• W2008576446 cites W1673643619 @default.
• W2008576446 cites W1853704205 @default.
• W2008576446 cites W1905912155 @default.
• W2008576446 cites W1974903851 @default.
• W2008576446 cites W1975577875 @default.
• W2008576446 cites W1988698591 @default.
• W2008576446 cites W1997107243 @default.
• W2008576446 cites W2005638080 @default.
• W2008576446 cites W2006729920 @default.
• W2008576446 cites W2006826160 @default.
• W2008576446 cites W2015338496 @default.
• W2008576446 cites W2023103815 @default.
• W2008576446 cites W2036264929 @default.
• W2008576446 cites W2038115763 @default.
• W2008576446 cites W2045679498 @default.
• W2008576446 cites W2047402683 @default.
• W2008576446 cites W2052734417 @default.
• W2008576446 cites W2055489437 @default.
• W2008576446 cites W2076958624 @default.
• W2008576446 cites W2078797757 @default.
• W2008576446 cites W2084863129 @default.
• W2008576446 cites W2089673998 @default.
• W2008576446 cites W2096415778 @default.
• W2008576446 cites W2097373408 @default.
• W2008576446 cites W2099690168 @default.
• W2008576446 cites W2101398318 @default.
• W2008576446 cites W2101517420 @default.
• W2008576446 cites W2102969047 @default.
• W2008576446 cites W2109240520 @default.
• W2008576446 cites W2114422950 @default.
• W2008576446 cites W2115541452 @default.
• W2008576446 cites W2121535168 @default.
• W2008576446 cites W2126504358 @default.
• W2008576446 cites W2129851137 @default.
• W2008576446 cites W2130137701 @default.
• W2008576446 cites W2136140812 @default.
• W2008576446 cites W2137428220 @default.
• W2008576446 cites W2137758263 @default.
• W2008576446 cites W2142610314 @default.
• W2008576446 cites W2154056804 @default.
• W2008576446 cites W2158734599 @default.
• W2008576446 cites W2159400887 @default.
• W2008576446 cites W2165209993 @default.
• W2008576446 cites W2166495119 @default.
• W2008576446 cites W2171046634 @default.
• W2008576446 doi "https://doi.org/10.1002/pros.22481" @default.
• W2008576446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3369116" @default.
• W2008576446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22213159" @default.
• W2008576446 hasPublicationYear "2011" @default.
• W2008576446 type Work @default.
• W2008576446 sameAs 2008576446 @default.
• W2008576446 citedByCount "20" @default.
• W2008576446 countsByYear W20085764462012 @default.
• W2008576446 countsByYear W20085764462013 @default.
• W2008576446 countsByYear W20085764462014 @default.
• W2008576446 countsByYear W20085764462015 @default.
• W2008576446 countsByYear W20085764462016 @default.
• W2008576446 countsByYear W20085764462017 @default.
• W2008576446 countsByYear W20085764462019 @default.
• W2008576446 countsByYear W20085764462020 @default.
• W2008576446 countsByYear W20085764462022 @default.
• W2008576446 countsByYear W20085764462023 @default.
• W2008576446 crossrefType "journal-article" @default.
• W2008576446 hasAuthorship W2008576446A5000198604 @default.
• W2008576446 hasAuthorship W2008576446A5012197303 @default.
• W2008576446 hasAuthorship W2008576446A5016182502 @default.
• W2008576446 hasAuthorship W2008576446A5016334197 @default.
• W2008576446 hasAuthorship W2008576446A5035773159 @default.
• W2008576446 hasAuthorship W2008576446A5037867453 @default.
• W2008576446 hasAuthorship W2008576446A5043787548 @default.
• W2008576446 hasAuthorship W2008576446A5049134760 @default.
• W2008576446 hasAuthorship W2008576446A5053941488 @default.
• W2008576446 hasAuthorship W2008576446A5054035098 @default.
• W2008576446 hasBestOaLocation W20085764462 @default.
• W2008576446 hasConcept C121608353 @default.
• W2008576446 hasConcept C126322002 @default.
• W2008576446 hasConcept C143998085 @default.
• W2008576446 hasConcept C150903083 @default.
• W2008576446 hasConcept C170493617 @default.
• W2008576446 hasConcept C180361614 @default.
• W2008576446 hasConcept C207001950 @default.

• next