Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008581684> ?p ?o ?g. }
- W2008581684 endingPage "218" @default.
- W2008581684 startingPage "207" @default.
- W2008581684 abstract "mTORC1 plays a key role in autophagy as a negative regulator. The currently known targets of mTORC1 in the autophagy pathway mainly function at early stages of autophagosome formation. Here, we identify that mTORC1 inhibits later stages of autophagy by phosphorylating UVRAG. Under nutrient-enriched conditions, mTORC1 binds and phosphorylates UVRAG. The phosphorylation positively regulates the association of UVRAG with RUBICON, thereby enhancing the antagonizing effect of RUBICON on UVRAG-mediated autophagosome maturation. Upon dephosphorylation, UVRAG is released from RUBICON to interact with the HOPS complex, a component for the late endosome and lysosome fusion machinery, and enhances autophagosome and endosome maturation. Consequently, the dephosphorylation of UVRAG facilitates the lysosomal degradation of epidermal growth factor receptor (EGFR), reduces EGFR signaling, and suppresses cancer cell proliferation and tumor growth. These results demonstrate that mTORC1 engages in late stages of autophagy and endosome maturation, defining a broader range of mTORC1 functions in the membrane-associated processes." @default.
- W2008581684 created "2016-06-24" @default.
- W2008581684 creator A5009496552 @default.
- W2008581684 creator A5029489184 @default.
- W2008581684 creator A5030936631 @default.
- W2008581684 creator A5036399753 @default.
- W2008581684 creator A5046688257 @default.
- W2008581684 creator A5067554657 @default.
- W2008581684 creator A5088724351 @default.
- W2008581684 date "2015-01-01" @default.
- W2008581684 modified "2023-10-14" @default.
- W2008581684 title "mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation" @default.
- W2008581684 cites W1519450813 @default.
- W2008581684 cites W1918384196 @default.
- W2008581684 cites W1966828940 @default.
- W2008581684 cites W1970637701 @default.
- W2008581684 cites W1971444034 @default.
- W2008581684 cites W1974485263 @default.
- W2008581684 cites W1983831622 @default.
- W2008581684 cites W1984537066 @default.
- W2008581684 cites W1994823455 @default.
- W2008581684 cites W2002636911 @default.
- W2008581684 cites W2004582874 @default.
- W2008581684 cites W2005823843 @default.
- W2008581684 cites W2006559495 @default.
- W2008581684 cites W2023445018 @default.
- W2008581684 cites W2025176940 @default.
- W2008581684 cites W2053038488 @default.
- W2008581684 cites W2053981201 @default.
- W2008581684 cites W2060349031 @default.
- W2008581684 cites W2065887259 @default.
- W2008581684 cites W2066659565 @default.
- W2008581684 cites W2066697766 @default.
- W2008581684 cites W2067683713 @default.
- W2008581684 cites W2089695512 @default.
- W2008581684 cites W2092321143 @default.
- W2008581684 cites W2103659405 @default.
- W2008581684 cites W2105044604 @default.
- W2008581684 cites W2109034822 @default.
- W2008581684 cites W2112810120 @default.
- W2008581684 cites W2113432343 @default.
- W2008581684 cites W2122826962 @default.
- W2008581684 cites W2127063807 @default.
- W2008581684 cites W2133284292 @default.
- W2008581684 cites W2134106182 @default.
- W2008581684 cites W2137095142 @default.
- W2008581684 cites W2154993563 @default.
- W2008581684 cites W2155175976 @default.
- W2008581684 cites W2155810842 @default.
- W2008581684 cites W2156144699 @default.
- W2008581684 cites W2161050915 @default.
- W2008581684 cites W2162496416 @default.
- W2008581684 cites W2167153850 @default.
- W2008581684 doi "https://doi.org/10.1016/j.molcel.2014.11.013" @default.
- W2008581684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4304967" @default.
- W2008581684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25533187" @default.
- W2008581684 hasPublicationYear "2015" @default.
- W2008581684 type Work @default.
- W2008581684 sameAs 2008581684 @default.
- W2008581684 citedByCount "210" @default.
- W2008581684 countsByYear W20085816842015 @default.
- W2008581684 countsByYear W20085816842016 @default.
- W2008581684 countsByYear W20085816842017 @default.
- W2008581684 countsByYear W20085816842018 @default.
- W2008581684 countsByYear W20085816842019 @default.
- W2008581684 countsByYear W20085816842020 @default.
- W2008581684 countsByYear W20085816842021 @default.
- W2008581684 countsByYear W20085816842022 @default.
- W2008581684 countsByYear W20085816842023 @default.
- W2008581684 crossrefType "journal-article" @default.
- W2008581684 hasAuthorship W2008581684A5009496552 @default.
- W2008581684 hasAuthorship W2008581684A5029489184 @default.
- W2008581684 hasAuthorship W2008581684A5030936631 @default.
- W2008581684 hasAuthorship W2008581684A5036399753 @default.
- W2008581684 hasAuthorship W2008581684A5046688257 @default.
- W2008581684 hasAuthorship W2008581684A5067554657 @default.
- W2008581684 hasAuthorship W2008581684A5088724351 @default.
- W2008581684 hasBestOaLocation W20085816841 @default.
- W2008581684 hasConcept C102747710 @default.
- W2008581684 hasConcept C11960822 @default.
- W2008581684 hasConcept C168296220 @default.
- W2008581684 hasConcept C178666793 @default.
- W2008581684 hasConcept C181912034 @default.
- W2008581684 hasConcept C190283241 @default.
- W2008581684 hasConcept C203522944 @default.
- W2008581684 hasConcept C55493867 @default.
- W2008581684 hasConcept C75217442 @default.
- W2008581684 hasConcept C79879829 @default.
- W2008581684 hasConcept C86803240 @default.
- W2008581684 hasConcept C95444343 @default.
- W2008581684 hasConcept C98490376 @default.
- W2008581684 hasConceptScore W2008581684C102747710 @default.
- W2008581684 hasConceptScore W2008581684C11960822 @default.
- W2008581684 hasConceptScore W2008581684C168296220 @default.
- W2008581684 hasConceptScore W2008581684C178666793 @default.
- W2008581684 hasConceptScore W2008581684C181912034 @default.
- W2008581684 hasConceptScore W2008581684C190283241 @default.
- W2008581684 hasConceptScore W2008581684C203522944 @default.