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• W2008584755 abstract "The immature rat brain is highly susceptible to seizures, but has a resistance to pathological changes induced by seizures as compared to adult rats. However, prolonged seizures during early-life enhance cellular injury and hyperexcitability induced by convulsive insults later in adulthood. The mechanisms underlying these phenomena are not understood. In adult models, the CA1 axons reorganize their projections to subiculum. Seizure induced plasticity in this pathway has not been investigated in immature seizure models, and may contribute to the vulnerability to later seizures. On postnatal day 15, rats experienced convulsive status epilepticus with kainic acid (KA). Seizure induced plasticity was examined with Timm histochemistry and iontophoretic injections of sodium selenite, a retrograde tracer. Cellular injury was evaluated with Fluoro-Jade B histochemistry. Retrograde tracing experiments determined a 67% larger dorsoventral extent of retrograde labeling in the CA1 pyramidal region after tracer injections in subiculum. The synaptic reorganization of the CA1 projection to subiculum was noted in the absence of overt neuronal injury in subiculum or CA1. In contrast, mossy fiber sprouting was detected into the stratum oriens of CA3 with limited neuronal injury to CA3 pyramidal neurons. No mossy fiber sprouting into the inner molecular layer of the dentate gyrus, or CA1 sprouting into the stratum moleculare of CA1 were noted. The results indicate that the developing brain has distinct mechanisms of seizure induced reorganization as compared to the adult brain. Our experiments show that the concept of “resistance of the immature brain to excitotoxicity” is considerably more complicated than generally believed. Morphological plasticity in the immature brain appears more extensive in distal, but not proximal, projections of hippocampal pathways, and across hippocampal lamellae. The abnormal connectivity between hippocampal lamellae might play a role in the increased susceptibility to injury and hyperexcitability associated with later convulsive insults." @default.
• W2008584755 created "2016-06-24" @default.
• W2008584755 creator A5029534475 @default.
• W2008584755 creator A5085534089 @default.
• W2008584755 date "2007-02-01" @default.
• W2008584755 modified "2023-10-17" @default.
• W2008584755 title "Synaptic reorganization in subiculum and CA3 after early-life status epilepticus in the kainic acid rat model" @default.
• W2008584755 cites W1561828919 @default.
• W2008584755 cites W1574757902 @default.
• W2008584755 cites W1827373965 @default.
• W2008584755 cites W1872719817 @default.
• W2008584755 cites W1964389840 @default.
• W2008584755 cites W1967010346 @default.
• W2008584755 cites W1971444467 @default.
• W2008584755 cites W1972988611 @default.
• W2008584755 cites W1976639286 @default.
• W2008584755 cites W1979723988 @default.
• W2008584755 cites W1983792602 @default.
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• W2008584755 cites W2000203581 @default.
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• W2008584755 cites W2002383211 @default.
• W2008584755 cites W2003385862 @default.
• W2008584755 cites W2005393221 @default.
• W2008584755 cites W2008029686 @default.
• W2008584755 cites W2008566400 @default.
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• W2008584755 cites W2013719288 @default.
• W2008584755 cites W2014263725 @default.
• W2008584755 cites W2016489565 @default.
• W2008584755 cites W2016815767 @default.
• W2008584755 cites W2018046195 @default.
• W2008584755 cites W2031118854 @default.
• W2008584755 cites W2035562497 @default.
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• W2008584755 cites W2039037872 @default.
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• W2008584755 cites W2046912627 @default.
• W2008584755 cites W2051920069 @default.
• W2008584755 cites W2064363302 @default.
• W2008584755 cites W2067375023 @default.
• W2008584755 cites W2069586118 @default.
• W2008584755 cites W2070864731 @default.
• W2008584755 cites W2076109228 @default.
• W2008584755 cites W2077369265 @default.
• W2008584755 cites W2077915215 @default.
• W2008584755 cites W2080624758 @default.
• W2008584755 cites W2083165258 @default.
• W2008584755 cites W2088017716 @default.
• W2008584755 cites W2091160631 @default.
• W2008584755 cites W2091441008 @default.
• W2008584755 cites W2092959372 @default.
• W2008584755 cites W2107518032 @default.
• W2008584755 cites W2127097320 @default.
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• W2008584755 cites W2149846553 @default.
• W2008584755 cites W2168814838 @default.
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• W2008584755 cites W2409336322 @default.
• W2008584755 cites W2409927356 @default.
• W2008584755 cites W2412260864 @default.
• W2008584755 cites W2993440152 @default.
• W2008584755 cites W4243970087 @default.
• W2008584755 cites W963517183 @default.
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• W2008584755 doi "https://doi.org/10.1016/j.eplepsyres.2006.09.004" @default.
• W2008584755 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1876715" @default.
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