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• W2008589032 abstract "Immunological mechanisms may play a role in the pathogenesis of insulin-dependent diabetes mellitus (IDDM), and suppressor cell activity (SCA) has been found depressed at diagnosis. The aim of the present study was to elucidate whether patients with preserved beta-cell function display a different SCA than other patients. Sixteen patients without and 12 patients with beta-cell function after averagely 9 years' duration of IDDM were examined. The suppressive effect of lymphocytes was investigated after incubation with concanavalin A followed by inactivation. Suppression was measured as the ability of the lymphocytes to inhibit 3H-thymidine incorporation in concanavalin A stimulated normal donor lymphocytes. The main findings were: (1) No significant differences in SCA between patients with and without beta-cell function, and one of these patient groups had SCA significantly different from normal controls. (2) A correlation between SCA and administered dose of insulin among patients without beta-cell function. It is concluded that the actual SCA several years after diagnosis is not connected with the beta-cell function in patients with IDDM." @default.
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• W2008589032 date "1982-11-01" @default.
• W2008589032 modified "2023-10-16" @default.
• W2008589032 title "SUPPRESSOR CELL ACTIVITY AND BETA-CELL FUNCTION IN INSULIN-DEPENDENT DIABETICS" @default.
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• W2008589032 doi "https://doi.org/10.1111/j.1699-0463.1982.tb01417.x" @default.
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