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- W2008589066 abstract "The effect of a single subcutaneous dose of 200 mg/kg body weight dichlorvos on neuronal microtubule phosphorylation has been studied in rat following the development of organophosphate induced delayed neurotoxicity (OPIDN). Microtubule associated Ca2+/calmodulin dependent as well as cAMP dependent protein kinases were assayed. Dichlorvos administration led to a consistent increase in the activity of both the kinases at all post exposure intervals (7th, 15th and 21st day) as compared to that of controls. After in vitro phosphorylation using [γ-32P]ATP, various proteins were resolved on one-dimensional 8% SDS–PAGE, stained with Coomassie Blue and autoradiographed. The amount of 32P incorporated was quantified by microdensitometry. Dichlorvos enhanced the phosphorylation of 55- and 280-kDa proteins. These two proteins were identified as tubulin and microtubule associated protein-2 (MAP-2) by immunoblotting. This study showed that dichlorvos induced hyperphosphorylation of tubulin and MAP-2 which in turn destabilizes microtubule assembly, and may ultimately result in axonal degeneration leading to dichlorvos induced delayed neurotoxicity." @default.
- W2008589066 created "2016-06-24" @default.
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- W2008589066 date "2001-04-01" @default.
- W2008589066 modified "2023-10-14" @default.
- W2008589066 title "Possible role of enhanced microtubule phosphorylation in dichlorvos induced delayed neurotoxicity in rat" @default.
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- W2008589066 doi "https://doi.org/10.1016/s0006-8993(00)03222-4" @default.
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