Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008589980> ?p ?o ?g. }
- W2008589980 endingPage "158" @default.
- W2008589980 startingPage "144" @default.
- W2008589980 abstract "Structure based design, synthesis, and biological evaluation of a novel series of 1-methyl-1H-imidazole, as potent Jak2 inhibitors to modulate the Jak/STAT pathway, are described. Using the C-ring fragment from our first clinical candidate AZD1480 (24), optimization of the series led to the discovery of compound 19a, a potent, orally bioavailable Jak2 inhibitor. Compound 19a displayed a high level of cellular activity in hematopoietic cell lines harboring the V617F mutation and in murine BaF3 TEL-Jak2 cells. Compound 19a demonstrated significant tumor growth inhibition in a UKE-1 xenograft model within a well-tolerated dose range." @default.
- W2008589980 created "2016-06-24" @default.
- W2008589980 creator A5001064231 @default.
- W2008589980 creator A5010293166 @default.
- W2008589980 creator A5018924446 @default.
- W2008589980 creator A5024143296 @default.
- W2008589980 creator A5030065450 @default.
- W2008589980 creator A5033356973 @default.
- W2008589980 creator A5035737049 @default.
- W2008589980 creator A5038935034 @default.
- W2008589980 creator A5042359123 @default.
- W2008589980 creator A5042406680 @default.
- W2008589980 creator A5044437841 @default.
- W2008589980 creator A5048516275 @default.
- W2008589980 creator A5057480173 @default.
- W2008589980 creator A5064449216 @default.
- W2008589980 creator A5067040049 @default.
- W2008589980 creator A5070431667 @default.
- W2008589980 creator A5084912813 @default.
- W2008589980 date "2013-12-20" @default.
- W2008589980 modified "2023-10-01" @default.
- W2008589980 title "Discovery of 1-Methyl-1<i>H</i>-imidazole Derivatives as Potent Jak2 Inhibitors" @default.
- W2008589980 cites W1968112651 @default.
- W2008589980 cites W1973160387 @default.
- W2008589980 cites W1978522011 @default.
- W2008589980 cites W1980337077 @default.
- W2008589980 cites W1981387370 @default.
- W2008589980 cites W1989877475 @default.
- W2008589980 cites W2001425106 @default.
- W2008589980 cites W2001641653 @default.
- W2008589980 cites W2004795787 @default.
- W2008589980 cites W2008799537 @default.
- W2008589980 cites W2010293026 @default.
- W2008589980 cites W2010326322 @default.
- W2008589980 cites W2012828222 @default.
- W2008589980 cites W2017715430 @default.
- W2008589980 cites W2018062526 @default.
- W2008589980 cites W2018895990 @default.
- W2008589980 cites W2029494734 @default.
- W2008589980 cites W2032817710 @default.
- W2008589980 cites W2037984456 @default.
- W2008589980 cites W2038840577 @default.
- W2008589980 cites W2040381937 @default.
- W2008589980 cites W2049145190 @default.
- W2008589980 cites W2057360098 @default.
- W2008589980 cites W2075214128 @default.
- W2008589980 cites W2076752985 @default.
- W2008589980 cites W2090762415 @default.
- W2008589980 cites W2094849619 @default.
- W2008589980 cites W2095244598 @default.
- W2008589980 cites W2102985093 @default.
- W2008589980 cites W2111109297 @default.
- W2008589980 cites W2123633897 @default.
- W2008589980 cites W2132435276 @default.
- W2008589980 cites W2133197493 @default.
- W2008589980 cites W2144081223 @default.
- W2008589980 cites W2144664431 @default.
- W2008589980 cites W2402625670 @default.
- W2008589980 doi "https://doi.org/10.1021/jm401546n" @default.
- W2008589980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24359159" @default.
- W2008589980 hasPublicationYear "2013" @default.
- W2008589980 type Work @default.
- W2008589980 sameAs 2008589980 @default.
- W2008589980 citedByCount "48" @default.
- W2008589980 countsByYear W20085899802014 @default.
- W2008589980 countsByYear W20085899802015 @default.
- W2008589980 countsByYear W20085899802016 @default.
- W2008589980 countsByYear W20085899802017 @default.
- W2008589980 countsByYear W20085899802018 @default.
- W2008589980 countsByYear W20085899802019 @default.
- W2008589980 countsByYear W20085899802020 @default.
- W2008589980 countsByYear W20085899802021 @default.
- W2008589980 countsByYear W20085899802022 @default.
- W2008589980 countsByYear W20085899802023 @default.
- W2008589980 crossrefType "journal-article" @default.
- W2008589980 hasAuthorship W2008589980A5001064231 @default.
- W2008589980 hasAuthorship W2008589980A5010293166 @default.
- W2008589980 hasAuthorship W2008589980A5018924446 @default.
- W2008589980 hasAuthorship W2008589980A5024143296 @default.
- W2008589980 hasAuthorship W2008589980A5030065450 @default.
- W2008589980 hasAuthorship W2008589980A5033356973 @default.
- W2008589980 hasAuthorship W2008589980A5035737049 @default.
- W2008589980 hasAuthorship W2008589980A5038935034 @default.
- W2008589980 hasAuthorship W2008589980A5042359123 @default.
- W2008589980 hasAuthorship W2008589980A5042406680 @default.
- W2008589980 hasAuthorship W2008589980A5044437841 @default.
- W2008589980 hasAuthorship W2008589980A5048516275 @default.
- W2008589980 hasAuthorship W2008589980A5057480173 @default.
- W2008589980 hasAuthorship W2008589980A5064449216 @default.
- W2008589980 hasAuthorship W2008589980A5067040049 @default.
- W2008589980 hasAuthorship W2008589980A5070431667 @default.
- W2008589980 hasAuthorship W2008589980A5084912813 @default.
- W2008589980 hasConcept C185592680 @default.
- W2008589980 hasConcept C193042331 @default.
- W2008589980 hasConcept C202751555 @default.
- W2008589980 hasConcept C2780874372 @default.
- W2008589980 hasConcept C54355233 @default.
- W2008589980 hasConcept C55493867 @default.