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• W2008598502 abstract "SUMMARY Ligand-gated chloride channels, including the glutamate-(GluCl) and GABA-gated channels, are the targets of the macrocyclic lactone (ML) family of anthelmintics. Changes in the sequence and expression of these channels can cause resistance to the ML in laboratory models, such as Caenorhabditis elegans and Drosophila melanogaster . Mutations in multiple GluCl subunit genes are required for high-level ML resistance in C. elegans , and this can be influenced by additional mutations in gap junction and amphid genes. Parasitic nematodes have a different complement of channel subunit genes from C. elegans , but a few genes, including avr-14 , are widely present. A polymorphism in an avr-14 orthologue, which makes the subunit less sensitive to ivermectin and glutamate, has been identified in Cooperia oncophora , and polymorphisms in several subunits have been reported from resistant isolates of Haemonchus contortus . This has led to suggestions that ML resistance may be polygenic. Possible reasons for this, and its consequences for the development of molecular tests for resistance, are explored." @default.
• W2008598502 created "2016-06-24" @default.
• W2008598502 creator A5015072206 @default.
• W2008598502 creator A5053039267 @default.
• W2008598502 creator A5060098347 @default.
• W2008598502 date "2007-07-03" @default.
• W2008598502 modified "2023-09-27" @default.
• W2008598502 title "Nematode ligand-gated chloride channels: an appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers" @default.
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• W2008598502 doi "https://doi.org/10.1017/s0031182007000042" @default.
• W2008598502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17608971" @default.
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