FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008604843> ?p ?o ?g. }

• W2008604843 endingPage "195" @default.
• W2008604843 startingPage "187" @default.
• W2008604843 abstract "Vascular endothelial growth factor (VEGF) is an angiogenic growth factor which binds to two structually related tyrosine kinase receptors denoted KDR and FLT1. To compare the interaction of VEGF with each receptor, cell lines which express individual receptor subtypes were identified using Northern blot hybridization. Bovine aortic endothelial (ABAE) cells and WM35 melanoma cells were found to express KDR, while FLT1 was primarily expressed on SK-MEL-37. Both receptor subtypes were detected on another melanoma cell line (WM9). Heparin augmented VEGF binding to KDR-expressing cells (ABAE and WM35), but inhibited VEGF binding to FLT 1-expressing cells (SK-MEL-37 and WM9). The concentration of heparin required for half maximal stimulation of VEGF binding to KDR-expressing cells (500 ng/ml) was 25 times greater than that required for half maximal inhibition of binding to FLT1-expressing cells (20 ng/ml). In WM9 cells, the effect of heparin was bimodal; low concentration inhibited, while higher concentrations stimulated binding of 125I-VEGF. Placenta growth factor (PlGF-1) is a recently described growth factor structurally similar to VEGF. PlGF-1 had a negligible or no effect on 125I-VEGF binding to KDR-expressing cells (ABAE, WM35), but did compete for binding to FLT1 expressing cells (SK-MEL-37 and WM9). Addition of heparin had no effect on its ability to compete for binding with 125I-VEGF. The data indicate differential regulation of the two VEGF receptors by heparin and extended specificity of FLT1 receptor, but not KDR, for binding PlGF-1 growth factor." @default.
• W2008604843 created "2016-06-24" @default.
• W2008604843 creator A5014761981 @default.
• W2008604843 creator A5017453593 @default.
• W2008604843 creator A5027681920 @default.
• W2008604843 creator A5029925301 @default.
• W2008604843 creator A5030507050 @default.
• W2008604843 creator A5055224102 @default.
• W2008604843 creator A5059035410 @default.
• W2008604843 creator A5082038516 @default.
• W2008604843 creator A5083502096 @default.
• W2008604843 date "1994-01-01" @default.
• W2008604843 modified "2023-10-18" @default.
• W2008604843 title "VEGF Receptor Subtypes KDR and FLT1 Show Different Sensitivities to Heparin and Placenta Growth Factor" @default.
• W2008604843 cites W1499692647 @default.
• W2008604843 cites W1537712767 @default.
• W2008604843 cites W1562216431 @default.
• W2008604843 cites W1591057067 @default.
• W2008604843 cites W1972438151 @default.
• W2008604843 cites W1980384590 @default.
• W2008604843 cites W1981612052 @default.
• W2008604843 cites W1983649348 @default.
• W2008604843 cites W1983763042 @default.
• W2008604843 cites W1986469266 @default.
• W2008604843 cites W1991958278 @default.
• W2008604843 cites W1994821063 @default.
• W2008604843 cites W2002555237 @default.
• W2008604843 cites W2003598961 @default.
• W2008604843 cites W2013038209 @default.
• W2008604843 cites W2015344488 @default.
• W2008604843 cites W2023453327 @default.
• W2008604843 cites W2029763523 @default.
• W2008604843 cites W2043863730 @default.
• W2008604843 cites W2055987653 @default.
• W2008604843 cites W2062594120 @default.
• W2008604843 cites W2069092801 @default.
• W2008604843 cites W2084506573 @default.
• W2008604843 cites W2086611952 @default.
• W2008604843 cites W2114098415 @default.
• W2008604843 cites W2121220148 @default.
• W2008604843 cites W2167544720 @default.
• W2008604843 doi "https://doi.org/10.3109/08977199409046916" @default.
• W2008604843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7734144" @default.
• W2008604843 hasPublicationYear "1994" @default.
• W2008604843 type Work @default.
• W2008604843 sameAs 2008604843 @default.
• W2008604843 citedByCount "93" @default.
• W2008604843 countsByYear W20086048432012 @default.
• W2008604843 countsByYear W20086048432013 @default.
• W2008604843 countsByYear W20086048432014 @default.
• W2008604843 countsByYear W20086048432015 @default.
• W2008604843 countsByYear W20086048432016 @default.
• W2008604843 countsByYear W20086048432019 @default.
• W2008604843 countsByYear W20086048432021 @default.
• W2008604843 countsByYear W20086048432022 @default.
• W2008604843 crossrefType "journal-article" @default.
• W2008604843 hasAuthorship W2008604843A5014761981 @default.
• W2008604843 hasAuthorship W2008604843A5017453593 @default.
• W2008604843 hasAuthorship W2008604843A5027681920 @default.
• W2008604843 hasAuthorship W2008604843A5029925301 @default.
• W2008604843 hasAuthorship W2008604843A5030507050 @default.
• W2008604843 hasAuthorship W2008604843A5055224102 @default.
• W2008604843 hasAuthorship W2008604843A5059035410 @default.
• W2008604843 hasAuthorship W2008604843A5082038516 @default.
• W2008604843 hasAuthorship W2008604843A5083502096 @default.
• W2008604843 hasConcept C101544691 @default.
• W2008604843 hasConcept C126322002 @default.
• W2008604843 hasConcept C134018914 @default.
• W2008604843 hasConcept C146285616 @default.
• W2008604843 hasConcept C14858245 @default.
• W2008604843 hasConcept C153911025 @default.
• W2008604843 hasConcept C167734588 @default.
• W2008604843 hasConcept C170493617 @default.
• W2008604843 hasConcept C185592680 @default.
• W2008604843 hasConcept C2775960820 @default.
• W2008604843 hasConcept C2776871010 @default.
• W2008604843 hasConcept C2777025900 @default.
• W2008604843 hasConcept C42362537 @default.
• W2008604843 hasConcept C502942594 @default.
• W2008604843 hasConcept C55493867 @default.
• W2008604843 hasConcept C71924100 @default.
• W2008604843 hasConcept C86803240 @default.
• W2008604843 hasConceptScore W2008604843C101544691 @default.
• W2008604843 hasConceptScore W2008604843C126322002 @default.
• W2008604843 hasConceptScore W2008604843C134018914 @default.
• W2008604843 hasConceptScore W2008604843C146285616 @default.
• W2008604843 hasConceptScore W2008604843C14858245 @default.
• W2008604843 hasConceptScore W2008604843C153911025 @default.
• W2008604843 hasConceptScore W2008604843C167734588 @default.
• W2008604843 hasConceptScore W2008604843C170493617 @default.
• W2008604843 hasConceptScore W2008604843C185592680 @default.
• W2008604843 hasConceptScore W2008604843C2775960820 @default.
• W2008604843 hasConceptScore W2008604843C2776871010 @default.
• W2008604843 hasConceptScore W2008604843C2777025900 @default.
• W2008604843 hasConceptScore W2008604843C42362537 @default.
• W2008604843 hasConceptScore W2008604843C502942594 @default.
• W2008604843 hasConceptScore W2008604843C55493867 @default.
• W2008604843 hasConceptScore W2008604843C71924100 @default.

• next