Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008605652> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2008605652 endingPage "203" @default.
- W2008605652 startingPage "197" @default.
- W2008605652 abstract "The effect of microenvironment pH, humidity, and temperature was evaluated on the stability of polymorphic and amorphous forms of clopidogrel bisulfate, when present alone or in combinations. Oxalic acid and sodium carbonate were used as solid stressors to create acidic and alkaline pH, respectively. The samples without and with stressors were subjected for 3 months to (1) 0% RH, 25% RH, 75% RH, and 85% RH at 40 degrees C and also to (2) 60 degrees C, 80 degrees C, and 100 degrees C at 0% RH. In case of solid samples without stressors, the mixture of polymorphic and amorphous forms showed more degradation than the individual forms above critical relative humidity (85% RH). Similar higher degradation was observed between 75% RH and 85% RH in case of acid-stressed samples. In alkaline microenvironment, all the samples showed identical decomposition attributed to conversion of bisulfate salt to free base. Thermal studies indicated that polymorphic forms of clopidogrel bisulfate and also its glassy amorphous form were highly resistant to temperature, whereas the rubbery state of the drug degraded significantly at temperatures of > or =80 degrees C." @default.
- W2008605652 created "2016-06-24" @default.
- W2008605652 creator A5058669512 @default.
- W2008605652 creator A5085708287 @default.
- W2008605652 creator A5087544485 @default.
- W2008605652 date "2010-01-29" @default.
- W2008605652 modified "2023-10-05" @default.
- W2008605652 title "Influence of Microenvironment pH, Humidity, and Temperature on the Stability of Polymorphic and Amorphous Forms of Clopidogrel Bisulfate" @default.
- W2008605652 cites W1976501857 @default.
- W2008605652 cites W1980704616 @default.
- W2008605652 cites W2026049752 @default.
- W2008605652 cites W2079848327 @default.
- W2008605652 cites W2088249126 @default.
- W2008605652 doi "https://doi.org/10.1208/s12249-010-9376-1" @default.
- W2008605652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2850473" @default.
- W2008605652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20112136" @default.
- W2008605652 hasPublicationYear "2010" @default.
- W2008605652 type Work @default.
- W2008605652 sameAs 2008605652 @default.
- W2008605652 citedByCount "12" @default.
- W2008605652 countsByYear W20086056522012 @default.
- W2008605652 countsByYear W20086056522013 @default.
- W2008605652 countsByYear W20086056522014 @default.
- W2008605652 countsByYear W20086056522015 @default.
- W2008605652 countsByYear W20086056522018 @default.
- W2008605652 countsByYear W20086056522019 @default.
- W2008605652 countsByYear W20086056522021 @default.
- W2008605652 countsByYear W20086056522022 @default.
- W2008605652 countsByYear W20086056522023 @default.
- W2008605652 crossrefType "journal-article" @default.
- W2008605652 hasAuthorship W2008605652A5058669512 @default.
- W2008605652 hasAuthorship W2008605652A5085708287 @default.
- W2008605652 hasAuthorship W2008605652A5087544485 @default.
- W2008605652 hasBestOaLocation W20086056522 @default.
- W2008605652 hasConcept C121332964 @default.
- W2008605652 hasConcept C13965031 @default.
- W2008605652 hasConcept C151420433 @default.
- W2008605652 hasConcept C158960510 @default.
- W2008605652 hasConcept C178790620 @default.
- W2008605652 hasConcept C179104552 @default.
- W2008605652 hasConcept C185592680 @default.
- W2008605652 hasConcept C2781346138 @default.
- W2008605652 hasConcept C56052488 @default.
- W2008605652 hasConcept C59061564 @default.
- W2008605652 hasConcept C97355855 @default.
- W2008605652 hasConceptScore W2008605652C121332964 @default.
- W2008605652 hasConceptScore W2008605652C13965031 @default.
- W2008605652 hasConceptScore W2008605652C151420433 @default.
- W2008605652 hasConceptScore W2008605652C158960510 @default.
- W2008605652 hasConceptScore W2008605652C178790620 @default.
- W2008605652 hasConceptScore W2008605652C179104552 @default.
- W2008605652 hasConceptScore W2008605652C185592680 @default.
- W2008605652 hasConceptScore W2008605652C2781346138 @default.
- W2008605652 hasConceptScore W2008605652C56052488 @default.
- W2008605652 hasConceptScore W2008605652C59061564 @default.
- W2008605652 hasConceptScore W2008605652C97355855 @default.
- W2008605652 hasIssue "1" @default.
- W2008605652 hasLocation W20086056521 @default.
- W2008605652 hasLocation W20086056522 @default.
- W2008605652 hasLocation W20086056523 @default.
- W2008605652 hasLocation W20086056524 @default.
- W2008605652 hasOpenAccess W2008605652 @default.
- W2008605652 hasPrimaryLocation W20086056521 @default.
- W2008605652 hasRelatedWork W1586733611 @default.
- W2008605652 hasRelatedWork W2013511864 @default.
- W2008605652 hasRelatedWork W2094150891 @default.
- W2008605652 hasRelatedWork W2108359751 @default.
- W2008605652 hasRelatedWork W2167781585 @default.
- W2008605652 hasRelatedWork W2332709929 @default.
- W2008605652 hasRelatedWork W2347905901 @default.
- W2008605652 hasRelatedWork W2366365583 @default.
- W2008605652 hasRelatedWork W2404169606 @default.
- W2008605652 hasRelatedWork W2181379992 @default.
- W2008605652 hasVolume "11" @default.
- W2008605652 isParatext "false" @default.
- W2008605652 isRetracted "false" @default.
- W2008605652 magId "2008605652" @default.
- W2008605652 workType "article" @default.