FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008608127> ?p ?o ?g. }

• W2008608127 endingPage "1037" @default.
• W2008608127 startingPage "1029" @default.
• W2008608127 abstract "1 The effect of lowering the temperature to near freezing-point upon the contractions and [3H]-inositol phosphate responses to carbachol were investigated in longitudinal smooth muscle from the guinea-pig ileum. 2 The peak amplitude of the contraction to a single application of 100 μm carbachol was the same at 37°C and temperatures near freezing-point. However, the sensitivity to carbachol was reduced upon lowering the temperature and the time to peak contraction was increased from 5–10 s to 2–10 min. Even when the temperature was maintained near freezing-point, washing off carbachol produced a relaxation and eventual return of tension to basal levels. 3 Incubating the tissue in 140 mm K+, calcium-free solution or in calcium channel antagonists significantly reduced the carbachol-induced contraction to 10–30% of the control at 37°C and also at 3°C. Thus the majority of the activator calcium required for contraction entered the tissue via voltage-dependent calcium channels (VDCs) at both 37°C and 3°C. 4 The contractions produced by high potassium solutions were less at temperatures close to freezing-point than those at 37°C suggesting that voltage-dependent calcium entry was inhibited as the temperature was lowered. 5 A small part of the contractile response to 100 μm carbachol was resistant to the removal of extracellular calcium at both 37°C and 3°C and this component was increased under depolarizing conditions. This suggests that the release of stored calcium contributes to a minor degree to contraction at both 37°C and 3°C. 6 Although 100 μm carbachol produced a statistically significant rise in several [3H]-inositol phosphate isomers at both 37°C and 3°C, the production of [3H]-inositol phosphates was less at 3°C than at 37°C and the increase in their production caused by carbachol was much slower. 7 These results suggest that the carbachol-induced contraction at 3°C utilizes both calcium entry through VDCs and calcium release from intracellular stores, as at 37°C. The components of the responses dependent upon intracellular calcium release at 37°C and at temperatures near freezing-point were similar. However, the production of [3H]-inositol phosphates, including the calcium-mobilizing second messenger inositol (1,4,5) trisphosphate (Ins(1,4,5)P3), is reduced at such low temperatures." @default.
• W2008608127 created "2016-06-24" @default.
• W2008608127 creator A5016564170 @default.
• W2008608127 creator A5029740841 @default.
• W2008608127 date "1993-08-01" @default.
• W2008608127 modified "2023-10-16" @default.
• W2008608127 title "Mechanism of carbachol-evoked contractions of guinea-pig ileal smooth muscle close to freezing point" @default.
• W2008608127 cites W133988147 @default.
• W2008608127 cites W1543977144 @default.
• W2008608127 cites W1626869678 @default.
• W2008608127 cites W1775749144 @default.
• W2008608127 cites W1844605916 @default.
• W2008608127 cites W1853779907 @default.
• W2008608127 cites W1877531625 @default.
• W2008608127 cites W1975681990 @default.
• W2008608127 cites W1992205858 @default.
• W2008608127 cites W1995519760 @default.
• W2008608127 cites W2001583718 @default.
• W2008608127 cites W2007450446 @default.
• W2008608127 cites W2014671477 @default.
• W2008608127 cites W2020423458 @default.
• W2008608127 cites W2022020819 @default.
• W2008608127 cites W2023351363 @default.
• W2008608127 cites W2044737826 @default.
• W2008608127 cites W2051091965 @default.
• W2008608127 cites W2066935607 @default.
• W2008608127 cites W2067786559 @default.
• W2008608127 cites W2089334064 @default.
• W2008608127 cites W2123621308 @default.
• W2008608127 cites W2125096014 @default.
• W2008608127 cites W2153110934 @default.
• W2008608127 cites W2259594190 @default.
• W2008608127 cites W2321217079 @default.
• W2008608127 cites W2338315462 @default.
• W2008608127 doi "https://doi.org/10.1111/j.1476-5381.1993.tb13725.x" @default.
• W2008608127 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2175742" @default.
• W2008608127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8401915" @default.
• W2008608127 hasPublicationYear "1993" @default.
• W2008608127 type Work @default.
• W2008608127 sameAs 2008608127 @default.
• W2008608127 citedByCount "10" @default.
• W2008608127 countsByYear W20086081272013 @default.
• W2008608127 countsByYear W20086081272018 @default.
• W2008608127 countsByYear W20086081272023 @default.
• W2008608127 crossrefType "journal-article" @default.
• W2008608127 hasAuthorship W2008608127A5016564170 @default.
• W2008608127 hasAuthorship W2008608127A5029740841 @default.
• W2008608127 hasBestOaLocation W20086081272 @default.
• W2008608127 hasConcept C12554922 @default.
• W2008608127 hasConcept C126322002 @default.
• W2008608127 hasConcept C134018914 @default.
• W2008608127 hasConcept C163415756 @default.
• W2008608127 hasConcept C178790620 @default.
• W2008608127 hasConcept C185592680 @default.
• W2008608127 hasConcept C24998067 @default.
• W2008608127 hasConcept C2776050358 @default.
• W2008608127 hasConcept C2778988552 @default.
• W2008608127 hasConcept C4141045 @default.
• W2008608127 hasConcept C517785266 @default.
• W2008608127 hasConcept C519063684 @default.
• W2008608127 hasConcept C71924100 @default.
• W2008608127 hasConcept C86803240 @default.
• W2008608127 hasConceptScore W2008608127C12554922 @default.
• W2008608127 hasConceptScore W2008608127C126322002 @default.
• W2008608127 hasConceptScore W2008608127C134018914 @default.
• W2008608127 hasConceptScore W2008608127C163415756 @default.
• W2008608127 hasConceptScore W2008608127C178790620 @default.
• W2008608127 hasConceptScore W2008608127C185592680 @default.
• W2008608127 hasConceptScore W2008608127C24998067 @default.
• W2008608127 hasConceptScore W2008608127C2776050358 @default.
• W2008608127 hasConceptScore W2008608127C2778988552 @default.
• W2008608127 hasConceptScore W2008608127C4141045 @default.
• W2008608127 hasConceptScore W2008608127C517785266 @default.
• W2008608127 hasConceptScore W2008608127C519063684 @default.
• W2008608127 hasConceptScore W2008608127C71924100 @default.
• W2008608127 hasConceptScore W2008608127C86803240 @default.
• W2008608127 hasIssue "4" @default.
• W2008608127 hasLocation W20086081271 @default.
• W2008608127 hasLocation W20086081272 @default.
• W2008608127 hasLocation W20086081273 @default.
• W2008608127 hasLocation W20086081274 @default.
• W2008608127 hasOpenAccess W2008608127 @default.
• W2008608127 hasPrimaryLocation W20086081271 @default.
• W2008608127 hasRelatedWork W2008608127 @default.
• W2008608127 hasRelatedWork W2022743462 @default.
• W2008608127 hasRelatedWork W2049732841 @default.
• W2008608127 hasRelatedWork W2063278633 @default.
• W2008608127 hasRelatedWork W2071201105 @default.
• W2008608127 hasRelatedWork W2145830981 @default.
• W2008608127 hasRelatedWork W2362448193 @default.
• W2008608127 hasRelatedWork W2393800486 @default.
• W2008608127 hasRelatedWork W2415017897 @default.
• W2008608127 hasRelatedWork W4253687864 @default.
• W2008608127 hasVolume "109" @default.
• W2008608127 isParatext "false" @default.
• W2008608127 isRetracted "false" @default.
• W2008608127 magId "2008608127" @default.
• W2008608127 workType "article" @default.