FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008627582> ?p ?o ?g. }

• W2008627582 endingPage "106" @default.
• W2008627582 startingPage "97" @default.
• W2008627582 abstract "Metabolic stresses associated with disease, ageing, and exercise increase the levels of reactive oxygen species (ROS) in skeletal muscle. These ROS have been linked mechanistically to adaptations in skeletal muscle that can be favourable (i.e. in response to exercise) or detrimental (i.e. in response to disease). The magnitude, duration (acute versus chronic), and cellular origin of the ROS are important underlying factors in determining the metabolic perturbations associated with the ROS produced in skeletal muscle. In particular, insulin resistance has been linked to excess ROS production in skeletal muscle mitochondria. A chronic excess of mitochondrial ROS can impair normal insulin signalling pathways and glucose disposal in skeletal muscle. In contrast, ROS produced in skeletal muscle in response to exercise has been linked to beneficial metabolic adaptations including mitochondrial biogenesis and muscle hypertrophy. Moreover, unlike insulin resistance, exercise-induced ROS appears to be primarily of non-mitochondrial origin. The present review summarizes the diverse ROS-targeted metabolic outcomes associated with insulin resistance versus exercise in skeletal muscle, thus, presenting two contrasting perspectives of pathologically harmful versus physiologically beneficial ROS. Here, we discuss the key sites of ROS production during exercise and the effect of ROS in skeletal muscle of people with type 2 diabetes." @default.
• W2008627582 created "2016-06-24" @default.
• W2008627582 creator A5057397617 @default.
• W2008627582 creator A5058003643 @default.
• W2008627582 date "2014-01-03" @default.
• W2008627582 modified "2023-10-17" @default.
• W2008627582 title "Skeletal muscle reactive oxygen species: A target of good cop/bad cop for exercise and disease" @default.
• W2008627582 cites W1480003811 @default.
• W2008627582 cites W1480123784 @default.
• W2008627582 cites W1509430244 @default.
• W2008627582 cites W1556914045 @default.
• W2008627582 cites W1701470710 @default.
• W2008627582 cites W1736629708 @default.
• W2008627582 cites W1838896829 @default.
• W2008627582 cites W1860472154 @default.
• W2008627582 cites W1947731682 @default.
• W2008627582 cites W1967964480 @default.
• W2008627582 cites W1968024017 @default.
• W2008627582 cites W1968183031 @default.
• W2008627582 cites W1968548369 @default.
• W2008627582 cites W1968991720 @default.
• W2008627582 cites W1971082641 @default.
• W2008627582 cites W1973185447 @default.
• W2008627582 cites W1973595217 @default.
• W2008627582 cites W1977064022 @default.
• W2008627582 cites W1980737938 @default.
• W2008627582 cites W1981864679 @default.
• W2008627582 cites W1982762531 @default.
• W2008627582 cites W1990119562 @default.
• W2008627582 cites W2008947334 @default.
• W2008627582 cites W2013482796 @default.
• W2008627582 cites W2014986242 @default.
• W2008627582 cites W2017709939 @default.
• W2008627582 cites W2018427433 @default.
• W2008627582 cites W2020614308 @default.
• W2008627582 cites W2020893322 @default.
• W2008627582 cites W2032172473 @default.
• W2008627582 cites W2032922626 @default.
• W2008627582 cites W2033377896 @default.
• W2008627582 cites W2035484071 @default.
• W2008627582 cites W2036227669 @default.
• W2008627582 cites W2038018821 @default.
• W2008627582 cites W2049175236 @default.
• W2008627582 cites W2049273909 @default.
• W2008627582 cites W2050380270 @default.
• W2008627582 cites W2053265995 @default.
• W2008627582 cites W2056833831 @default.
• W2008627582 cites W2057296064 @default.
• W2008627582 cites W2059016782 @default.
• W2008627582 cites W2060375326 @default.
• W2008627582 cites W2061437752 @default.
• W2008627582 cites W2063892426 @default.
• W2008627582 cites W2066040432 @default.
• W2008627582 cites W2066762257 @default.
• W2008627582 cites W2067087675 @default.
• W2008627582 cites W2067249065 @default.
• W2008627582 cites W2069466682 @default.
• W2008627582 cites W2070287747 @default.
• W2008627582 cites W2070548009 @default.
• W2008627582 cites W2071572735 @default.
• W2008627582 cites W2073540374 @default.
• W2008627582 cites W2075171810 @default.
• W2008627582 cites W2077645437 @default.
• W2008627582 cites W2084107123 @default.
• W2008627582 cites W2086483283 @default.
• W2008627582 cites W2087393295 @default.
• W2008627582 cites W2087561593 @default.
• W2008627582 cites W2090389306 @default.
• W2008627582 cites W2092913334 @default.
• W2008627582 cites W2098421398 @default.
• W2008627582 cites W2099547258 @default.
• W2008627582 cites W2100580265 @default.
• W2008627582 cites W2108462699 @default.
• W2008627582 cites W2112672163 @default.
• W2008627582 cites W2113529945 @default.
• W2008627582 cites W2114111268 @default.
• W2008627582 cites W2117396891 @default.
• W2008627582 cites W2118976195 @default.
• W2008627582 cites W2122341467 @default.
• W2008627582 cites W2122386753 @default.
• W2008627582 cites W2124557239 @default.
• W2008627582 cites W2125178416 @default.
• W2008627582 cites W2128294463 @default.
• W2008627582 cites W2133290655 @default.
• W2008627582 cites W2135788465 @default.
• W2008627582 cites W2138786739 @default.
• W2008627582 cites W2144728950 @default.
• W2008627582 cites W2148206007 @default.
• W2008627582 cites W2153541802 @default.
• W2008627582 cites W2154058662 @default.
• W2008627582 cites W2161479914 @default.
• W2008627582 cites W2162461126 @default.
• W2008627582 cites W2167088232 @default.
• W2008627582 cites W2172218838 @default.
• W2008627582 cites W2214291492 @default.
• W2008627582 cites W2281657435 @default.
• W2008627582 cites W2616663063 @default.
• W2008627582 cites W4235557285 @default.

• next