FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008635905> ?p ?o ?g. }

• W2008635905 endingPage "3388" @default.
• W2008635905 startingPage "3383" @default.
• W2008635905 abstract "Treatment of preterm infants with respiratory distress syndrome (RDS) with exogenous surfactant has greatly improved clinical outcome. Some infants require multiple doses, and it has not been studied whether these large amounts of exogenous surfactant disturb endogenous surfactant metabolism in humans. We studied endogenous surfactant metabolism in relation to different amounts of exogenous surfactant, administered as rescue therapy for RDS.Prospective clinical study.Neonatal intensive care unit in a university hospital.A total of 27 preterm infants intubated and mechanically ventilated for respiratory insufficiency.Infants received a 24-hr infusion with the stable isotope [U-13C]glucose starting 5.3 +/- 0.5 hrs after birth. The 13C-incorporation into palmitic acid in surfactant phosphatidylcholine (PC) isolated from serial tracheal aspirates was measured. Infants received either zero (n = 5), one (n = 4), two (n = 15), or three (n = 3) doses of Survanta (100 mg/kg) when clinically indicated.Using multiple regression analysis, the absolute synthesis rate (ASR) of surfactant PC from plasma glucose increased with 1.3 +/- 0.4 mg/kg/day per dose of Survanta (p = .007) (mean +/- SEM). The ASR of surfactant PC from glucose was increased by prenatal corticosteroid treatment with 1.3 +/- 0.4 mg/kg/day per dose corticosteroid (p = .004), and by the presence of a patent ductus arteriosus with 2.1 +/- 0.7 mg/ kg/day (p = .01).These data are reassuring and show for the first time in preterm infants that multiple doses of exogenous surfactant for RDS are tolerated well by the developing lung and stimulate endogenous surfactant synthesis." @default.
• W2008635905 created "2016-06-24" @default.
• W2008635905 creator A5001053552 @default.
• W2008635905 creator A5028109035 @default.
• W2008635905 creator A5030100313 @default.
• W2008635905 creator A5039160009 @default.
• W2008635905 creator A5070704847 @default.
• W2008635905 creator A5079684436 @default.
• W2008635905 creator A5087500433 @default.
• W2008635905 date "2000-10-01" @default.
• W2008635905 modified "2023-09-26" @default.
• W2008635905 title "Treatment with exogenous surfactant stimulates endogenous surfactant synthesis in premature infants with respiratory distress syndrome" @default.
• W2008635905 cites W1482782246 @default.
• W2008635905 cites W1499733109 @default.
• W2008635905 cites W1862849703 @default.
• W2008635905 cites W1934045024 @default.
• W2008635905 cites W1948175464 @default.
• W2008635905 cites W1971869602 @default.
• W2008635905 cites W1975038308 @default.
• W2008635905 cites W1976254427 @default.
• W2008635905 cites W1976395696 @default.
• W2008635905 cites W1978552525 @default.
• W2008635905 cites W1987720934 @default.
• W2008635905 cites W1989159174 @default.
• W2008635905 cites W1995159269 @default.
• W2008635905 cites W1999033288 @default.
• W2008635905 cites W2003891204 @default.
• W2008635905 cites W2017069757 @default.
• W2008635905 cites W2018571980 @default.
• W2008635905 cites W2019424764 @default.
• W2008635905 cites W2027168810 @default.
• W2008635905 cites W2037929872 @default.
• W2008635905 cites W2038751939 @default.
• W2008635905 cites W2042813913 @default.
• W2008635905 cites W2043555498 @default.
• W2008635905 cites W2046157124 @default.
• W2008635905 cites W2061859094 @default.
• W2008635905 cites W2061903286 @default.
• W2008635905 cites W2067911951 @default.
• W2008635905 cites W2071425528 @default.
• W2008635905 cites W2082668189 @default.
• W2008635905 cites W2082695277 @default.
• W2008635905 cites W2083670266 @default.
• W2008635905 cites W2087389288 @default.
• W2008635905 cites W2093713839 @default.
• W2008635905 cites W2094827305 @default.
• W2008635905 cites W2135452098 @default.
• W2008635905 cites W2168526937 @default.
• W2008635905 cites W2168701609 @default.
• W2008635905 cites W2179578038 @default.
• W2008635905 cites W2209500959 @default.
• W2008635905 cites W2300552860 @default.
• W2008635905 cites W2326167954 @default.
• W2008635905 cites W2335075431 @default.
• W2008635905 doi "https://doi.org/10.1097/00003246-200010000-00001" @default.
• W2008635905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11057790" @default.
• W2008635905 hasPublicationYear "2000" @default.
• W2008635905 type Work @default.
• W2008635905 sameAs 2008635905 @default.
• W2008635905 citedByCount "42" @default.
• W2008635905 countsByYear W20086359052012 @default.
• W2008635905 countsByYear W20086359052013 @default.
• W2008635905 countsByYear W20086359052016 @default.
• W2008635905 countsByYear W20086359052018 @default.
• W2008635905 countsByYear W20086359052019 @default.
• W2008635905 countsByYear W20086359052020 @default.
• W2008635905 countsByYear W20086359052023 @default.
• W2008635905 crossrefType "journal-article" @default.
• W2008635905 hasAuthorship W2008635905A5001053552 @default.
• W2008635905 hasAuthorship W2008635905A5028109035 @default.
• W2008635905 hasAuthorship W2008635905A5030100313 @default.
• W2008635905 hasAuthorship W2008635905A5039160009 @default.
• W2008635905 hasAuthorship W2008635905A5070704847 @default.
• W2008635905 hasAuthorship W2008635905A5079684436 @default.
• W2008635905 hasAuthorship W2008635905A5087500433 @default.
• W2008635905 hasConcept C126322002 @default.
• W2008635905 hasConcept C141983124 @default.
• W2008635905 hasConcept C185592680 @default.
• W2008635905 hasConcept C2776953283 @default.
• W2008635905 hasConcept C2778376644 @default.
• W2008635905 hasConcept C2778721537 @default.
• W2008635905 hasConcept C2779234561 @default.
• W2008635905 hasConcept C2780395437 @default.
• W2008635905 hasConcept C42219234 @default.
• W2008635905 hasConcept C54355233 @default.
• W2008635905 hasConcept C55493867 @default.
• W2008635905 hasConcept C58226133 @default.
• W2008635905 hasConcept C71924100 @default.
• W2008635905 hasConcept C86803240 @default.
• W2008635905 hasConcept C90924648 @default.
• W2008635905 hasConceptScore W2008635905C126322002 @default.
• W2008635905 hasConceptScore W2008635905C141983124 @default.
• W2008635905 hasConceptScore W2008635905C185592680 @default.
• W2008635905 hasConceptScore W2008635905C2776953283 @default.
• W2008635905 hasConceptScore W2008635905C2778376644 @default.
• W2008635905 hasConceptScore W2008635905C2778721537 @default.
• W2008635905 hasConceptScore W2008635905C2779234561 @default.
• W2008635905 hasConceptScore W2008635905C2780395437 @default.

• next