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- W2008641104 abstract "Increased total peripheral resistance is the cardinal haemodynamic disorder in essential hypertension. This could be secondary to alterations in the mechanical properties of vascular smooth muscle. Adequate study has not been made of the force–velocity (F–V) relationship in hypertensive arterial smooth muscle. Increased shortening in arterial smooth muscle would result in greater narrowing of arteries. The objectives of this investigation were to see if there is (i) increased shortening or increased maximum change in muscle length (ΔL max where L stands for muscle length), (ii) an increased maximum velocity of shortening (V max ) measured in l o per second where l o is the optimal muscle length for tension development, and (iii) a difference in maximum isometric tension (P o ) developed in spontaneously hypertensive rat (SHR; N = 6) compared with normotensive Wistar Kyoto rat (WKY; N = 5) caudal artery strips. An electromagnetic muscle lever was employed in recording force–velocity data. Analysis of these data revealed the following: (a) the SHR mean P o of 6.21 ± 1.01 N/cm 2 was not different from the mean WKY P o of 6.97 ± 1.64 N/cm 2 (p > 0.05); (b) the SHR preparations showed greater shortening for all loads imposed; (c) the SHR V max of 0.016 l o /s was greater than the WKY V max of 0.013 l o /s (p < 0.05). This study provides evidence that while hypertensive arterial smooth muscle is not able to produce more force than normotensive arterial smooth muscle, it is capable of faster and greater shortening. The latter could result in increased narrowing of hypertensive arteries and increased blood pressure." @default.
- W2008641104 created "2016-06-24" @default.
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- W2008641104 date "1985-06-01" @default.
- W2008641104 modified "2023-09-26" @default.
- W2008641104 title "Force–velocity relationships in hypertensive arterial smooth muscle" @default.
- W2008641104 doi "https://doi.org/10.1139/y85-111" @default.
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