FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008644745> ?p ?o ?g. }

• W2008644745 abstract "The bi-directional communication between the oocyte and its companion cumulus cells (CCs) is crucial for development and functions of both cell types. Transcripts that are exclusively expressed either in oocytes or CCs and molecular mechanisms affected due to removal of the communication axis between the two cell types is not investigated at a larger scale. The main objectives of this study were: 1. To identify transcripts exclusively expressed either in oocyte or CCs and 2. To identify those which are differentially expressed when the oocyte is cultured with or without its companion CCs and vice versa.We analyzed transcriptome profile of different oocyte and CC samples using Affymetrix GeneChip Bovine Genome array containing 23000 transcripts. Out of 13162 genes detected in germinal vesicle (GV) oocytes and their companion CCs, 1516 and 2727 are exclusively expressed in oocytes and CCs, respectively, while 8919 are expressed in both. Similarly, of 13602 genes detected in metaphase II (MII) oocytes and CCs, 1423 and 3100 are exclusively expressed in oocytes and CCs, respectively, while 9079 are expressed in both. A total of 265 transcripts are differentially expressed between oocytes cultured with (OO+CCs) and without (OO-CCs) CCs, of which 217 and 48 are over expressed in the former and the later groups, respectively. Similarly, 566 transcripts are differentially expressed when CCs mature with (CCs+OO) or without (CCs-OO) their enclosed oocytes. Of these, 320 and 246 are over expressed in CCs+OO and CCs-OO, respectively.While oocyte specific transcripts include those involved in transcription (IRF6, POU5F1, MYF5, MED18), translation (EIF2AK1, EIF4ENIF1) and CCs specific ones include those involved in carbohydrate metabolism (HYAL1, PFKL, PYGL, MPI), protein metabolic processes (IHH, APOA1, PLOD1), steroid biosynthetic process (APOA1, CYP11A1, HSD3B1, HSD3B7). Similarly, while transcripts over expressed in OO+CCs are involved in carbohydrate metabolism (ACO1, 2), molecular transport (GAPDH, GFPT1) and nucleic acid metabolism (CBS, NOS2), those over expressed in CCs+ OO are involved in cellular growth and proliferation (FOS, GADD45A), cell cycle (HAS2, VEGFA), cellular development (AMD1, AURKA, DPP4) and gene expression (FOSB, TGFB2).In conclusion, this study has generated large scale gene expression data from different oocyte and CCs samples that would provide insights into gene functions and interactions within and across different pathways that are involved in the maturation of bovine oocytes. Moreover, the presence or absence of oocyte and CC factors during bovine oocyte maturation can have a profound effect on transcript abundance of each cell types, thereby showing the prevailing molecular cross-talk between oocytes and their corresponding CCs." @default.
• W2008644745 created "2016-06-24" @default.
• W2008644745 creator A5038551081 @default.
• W2008644745 creator A5040221274 @default.
• W2008644745 creator A5041245667 @default.
• W2008644745 creator A5048600002 @default.
• W2008644745 creator A5054044642 @default.
• W2008644745 creator A5075621704 @default.
• W2008644745 creator A5078480003 @default.
• W2008644745 creator A5086546809 @default.
• W2008644745 date "2011-01-24" @default.
• W2008644745 modified "2023-10-08" @default.
• W2008644745 title "Transcriptome dynamics and molecular cross-talk between bovine oocyte and its companion cumulus cells" @default.
• W2008644745 cites W126837237 @default.
• W2008644745 cites W1530826550 @default.
• W2008644745 cites W1559205692 @default.
• W2008644745 cites W1577146075 @default.
• W2008644745 cites W1968446974 @default.
• W2008644745 cites W1972324826 @default.
• W2008644745 cites W1973973780 @default.
• W2008644745 cites W1974265269 @default.
• W2008644745 cites W1975298497 @default.
• W2008644745 cites W1978258909 @default.
• W2008644745 cites W1981088384 @default.
• W2008644745 cites W1981497491 @default.
• W2008644745 cites W1985360582 @default.
• W2008644745 cites W1987092404 @default.
• W2008644745 cites W1987610083 @default.
• W2008644745 cites W1989926395 @default.
• W2008644745 cites W1995618372 @default.
• W2008644745 cites W2000054693 @default.
• W2008644745 cites W2005764940 @default.
• W2008644745 cites W2008924154 @default.
• W2008644745 cites W2009754527 @default.
• W2008644745 cites W2012130857 @default.
• W2008644745 cites W2013239496 @default.
• W2008644745 cites W2014103983 @default.
• W2008644745 cites W2016570571 @default.
• W2008644745 cites W2017666826 @default.
• W2008644745 cites W2018707834 @default.
• W2008644745 cites W2023780628 @default.
• W2008644745 cites W2024639722 @default.
• W2008644745 cites W2033505317 @default.
• W2008644745 cites W2035536358 @default.
• W2008644745 cites W2037669421 @default.
• W2008644745 cites W2039707872 @default.
• W2008644745 cites W2041019830 @default.
• W2008644745 cites W2041689291 @default.
• W2008644745 cites W2042868184 @default.
• W2008644745 cites W2049618455 @default.
• W2008644745 cites W2053683231 @default.
• W2008644745 cites W2054801597 @default.
• W2008644745 cites W2061026525 @default.
• W2008644745 cites W2065476671 @default.
• W2008644745 cites W2066664707 @default.
• W2008644745 cites W2068510828 @default.
• W2008644745 cites W2072439295 @default.
• W2008644745 cites W2072925144 @default.
• W2008644745 cites W2075905225 @default.
• W2008644745 cites W2077634377 @default.
• W2008644745 cites W2082795476 @default.
• W2008644745 cites W2084241850 @default.
• W2008644745 cites W2085922126 @default.
• W2008644745 cites W2087130018 @default.
• W2008644745 cites W2088057711 @default.
• W2008644745 cites W2091042682 @default.
• W2008644745 cites W2096035039 @default.
• W2008644745 cites W2096642700 @default.
• W2008644745 cites W2096791952 @default.
• W2008644745 cites W2103017472 @default.
• W2008644745 cites W2103214426 @default.
• W2008644745 cites W2104210113 @default.
• W2008644745 cites W2105746559 @default.
• W2008644745 cites W2109972881 @default.
• W2008644745 cites W2110735000 @default.
• W2008644745 cites W2110912407 @default.
• W2008644745 cites W2111508487 @default.
• W2008644745 cites W2111513463 @default.
• W2008644745 cites W2113739044 @default.
• W2008644745 cites W2115286110 @default.
• W2008644745 cites W2116678605 @default.
• W2008644745 cites W2116842387 @default.
• W2008644745 cites W2118162811 @default.
• W2008644745 cites W2124069564 @default.
• W2008644745 cites W2124838379 @default.
• W2008644745 cites W2126364346 @default.
• W2008644745 cites W2126645741 @default.
• W2008644745 cites W2126722856 @default.
• W2008644745 cites W2127332827 @default.
• W2008644745 cites W2127859902 @default.
• W2008644745 cites W2130262016 @default.
• W2008644745 cites W2132772646 @default.
• W2008644745 cites W2132937662 @default.
• W2008644745 cites W2135104064 @default.
• W2008644745 cites W2135716875 @default.
• W2008644745 cites W2136180536 @default.
• W2008644745 cites W2138068158 @default.
• W2008644745 cites W2141075109 @default.
• W2008644745 cites W2141128578 @default.
• W2008644745 cites W2147020424 @default.

• next