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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008647600> ?p ?o ?g. }

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• W2008647600 abstract "Porcine aortic endothelial cells expressing platelet-derived growth factor (PDGF) α- or β-receptors after transfection of the corresponding cDNAs, were used to investigate whether PDGF receptor dimerization occurs in intact cells after ligand binding. Using three different methods—covalent cross-linking of 125I-labeled ligand, cross-linking of metabolically labeled cells after ligand-binding followed by immunoprecipitation, and immunoblotting of cells after ligand binding and cross-linking—it was demonstrated that α- as well as β-receptors form ligand-induced dimeric complexes. Dimerization correlated with induction of receptor kinase activity, measured as receptor autophosphorylation. Heterodimeric complexes could furthermore be induced by PDGF-AB, when added to a mixture of lysates from the α- and β-receptor expressing cell lines, or when added to human fibroblasts which express both receptor types." @default.
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• W2008647600 date "1992-01-01" @default.
• W2008647600 modified "2023-10-17" @default.
• W2008647600 title "Ligand-Induced Homo-and Hetero-Dimerization of Platelet-Derived Growth Factor α- and β-Receptors in Intact Cells" @default.
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• W2008647600 doi "https://doi.org/10.3109/08977199209008867" @default.
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