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• W2008652195 abstract "This study uses a one-dimensional model of cardiac strand to investigate the effects of electroporation on transmembrane potential (Vm) induced by defibrillation shocks. The strand is stimulated at the ends by extracellular electrodes. Its membrane, when exposed to large Vm, increases its conductance in a manner consistent with reversible electrical breakdown. Numerical simulations indicate that Vm increases proportionally to the shock strength only until the ends of the strand electroporate. Beyond this point, further increases in shock strength result in only a minor change in Vm. This arrest in the growth of Vm is caused by pores that develop in the cells immediately adjacent to the electrodes and that shunt part of the stimulating current directly into intracellular space. Consequently, only a fraction of the delivered current, Icr, gives rise to Vm; the current in excess of Icr divides itself proportionally between intra- and extracellular space and does not contribute to macroscopic Vm. Thus, electroporation has a beneficial effect: the formation of pores prevents the development of an excessively high Vm and limits the damage to the tissue. In contrast, electroporation does not affect the sawtooth component of Vm that reflects polarization of individual cells by electric field. These results indicate that electroporation does not impair the ability of the shock to reach the distant myocardium and may actually aid defibrillation by reducing nonuniformity of electrical conditions between regions close to the electrodes and in the bulk of tissue." @default.
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• W2008652195 creator A5070588034 @default.
• W2008652195 date "1995-09-01" @default.
• W2008652195 modified "2023-10-16" @default.
• W2008652195 title "Effects of Electroporation on Transmembrane Potential Induced by Defibrillation Shocks" @default.
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• W2008652195 doi "https://doi.org/10.1111/j.1540-8159.1995.tb06986.x" @default.
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