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- W2008654400 abstract "The APOBEC3 (A3) deaminases are retrovirus restriction factors that were proposed as inhibitory components of HIV-1 gene therapy vectors. However, A3 mutational activity may induce undesired genomic damage and enable HIV-1 to evade drugs and immune responses. Here, we show that A3A protein from Colobus guereza (colA3A) can restrict HIV-1 replication in producer cells in a deaminase-independent manner without inducing DNA damage. Neither HIV-1 reverse transcription nor integration were significantly affected by colA3A, but capsid protein synthesis was inhibited. The determinants for colA3A restriction mapped to the N-terminal region. These properties extend to A3A from mandrills and De Brazza׳s monkeys. Surprisingly, truncated colA3A proteins expressing only the N-terminal 100 amino acids effectively exclude critical catalytic regions but retained potent cellular restriction activity. These highlight a unique mechanism of cellular HIV-1 restriction by several Old World monkey A3A proteins that may be exploited for functional HIV-1 cure strategies." @default.
- W2008654400 created "2016-06-24" @default.
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- W2008654400 date "2014-11-01" @default.
- W2008654400 modified "2023-09-28" @default.
- W2008654400 title "Cellular HIV-1 inhibition by truncated old world primate APOBEC3A proteins lacking a complete deaminase domain" @default.
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- W2008654400 doi "https://doi.org/10.1016/j.virol.2014.09.001" @default.
- W2008654400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4252819" @default.
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