FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008657319> ?p ?o ?g. }

• W2008657319 endingPage "267" @default.
• W2008657319 startingPage "258" @default.
• W2008657319 abstract "The p53 transcription factor was first described over three decades ago and is one of the most studied proteins, with over 60,000 PubMed listed publications. Despite being first described as an oncogene, p53 has long been recognized as a major tumor suppressor and the most commonly mutated gene in human cancer. The frequent inactivation of p53 in tumors fostered the attractive notion that its functional reinstatement would constitute an effective tumor-specific therapy. Strategies aimed at restoring wild-type p53 function in tumors are being actively pursued and some have reached clinical trials, highlighting the important translational potential of this new field of research. The therapeutic impact of those strategies in human cancer was recently modeled in mice where a clear, even if limited, therapeutic benefit of p53-targeted therapies was established. As unexpected aspects of p53 tumor suppressive function continue to be uncovered, new opportunities arise to further improve p53 therapy outcome. In this review we discuss the in vivo mechanisms underlying p53-mediated tumor prevention, the impact of p53 functional restoration in tumors and how this knowledge may be exploited to improve the efficacy of p53-targeted cancer therapy. A particular emphasis is given to the newly identified metabolic functions of p53." @default.
• W2008657319 created "2016-06-24" @default.
• W2008657319 creator A5013887971 @default.
• W2008657319 creator A5063056955 @default.
• W2008657319 date "2012-10-01" @default.
• W2008657319 modified "2023-10-16" @default.
• W2008657319 title "From tumor prevention to therapy: Empowering p53 to fight back" @default.
• W2008657319 cites W1482923899 @default.
• W2008657319 cites W1531240647 @default.
• W2008657319 cites W1534987406 @default.
• W2008657319 cites W1591281137 @default.
• W2008657319 cites W1650797637 @default.
• W2008657319 cites W1680634601 @default.
• W2008657319 cites W1964781873 @default.
• W2008657319 cites W1966163762 @default.
• W2008657319 cites W1966571112 @default.
• W2008657319 cites W1968075505 @default.
• W2008657319 cites W1968625769 @default.
• W2008657319 cites W1969044026 @default.
• W2008657319 cites W1970249544 @default.
• W2008657319 cites W1970431885 @default.
• W2008657319 cites W1970527559 @default.
• W2008657319 cites W1973748124 @default.
• W2008657319 cites W1973886069 @default.
• W2008657319 cites W1976878409 @default.
• W2008657319 cites W1978554125 @default.
• W2008657319 cites W1978782811 @default.
• W2008657319 cites W1981079102 @default.
• W2008657319 cites W1984755213 @default.
• W2008657319 cites W1984885474 @default.
• W2008657319 cites W1984948591 @default.
• W2008657319 cites W1985064409 @default.
• W2008657319 cites W1991091416 @default.
• W2008657319 cites W1993864973 @default.
• W2008657319 cites W1994015824 @default.
• W2008657319 cites W1998166655 @default.
• W2008657319 cites W1998767677 @default.
• W2008657319 cites W1998943082 @default.
• W2008657319 cites W2003971548 @default.
• W2008657319 cites W2004273407 @default.
• W2008657319 cites W2004838336 @default.
• W2008657319 cites W2005155951 @default.
• W2008657319 cites W2009096172 @default.
• W2008657319 cites W2012053348 @default.
• W2008657319 cites W2013126678 @default.
• W2008657319 cites W2013607453 @default.
• W2008657319 cites W2013747211 @default.
• W2008657319 cites W2014780970 @default.
• W2008657319 cites W2014938226 @default.
• W2008657319 cites W2016301293 @default.
• W2008657319 cites W2018116689 @default.
• W2008657319 cites W2021536610 @default.
• W2008657319 cites W2029000257 @default.
• W2008657319 cites W2031628684 @default.
• W2008657319 cites W2032019019 @default.
• W2008657319 cites W2034882416 @default.
• W2008657319 cites W2035222813 @default.
• W2008657319 cites W2035608099 @default.
• W2008657319 cites W2038444562 @default.
• W2008657319 cites W2038652783 @default.
• W2008657319 cites W2042461504 @default.
• W2008657319 cites W2043107604 @default.
• W2008657319 cites W2051233997 @default.
• W2008657319 cites W2059999514 @default.
• W2008657319 cites W2062515127 @default.
• W2008657319 cites W2062811597 @default.
• W2008657319 cites W2065220409 @default.
• W2008657319 cites W2066218351 @default.
• W2008657319 cites W2068456988 @default.
• W2008657319 cites W2069466069 @default.
• W2008657319 cites W2072451938 @default.
• W2008657319 cites W2074017756 @default.
• W2008657319 cites W2074114480 @default.
• W2008657319 cites W2075300416 @default.
• W2008657319 cites W2082959665 @default.
• W2008657319 cites W2083659501 @default.
• W2008657319 cites W2084780592 @default.
• W2008657319 cites W2091151265 @default.
• W2008657319 cites W2092902276 @default.
• W2008657319 cites W2095987251 @default.
• W2008657319 cites W2096281488 @default.
• W2008657319 cites W2097933346 @default.
• W2008657319 cites W2099907467 @default.
• W2008657319 cites W2099987999 @default.
• W2008657319 cites W2104014368 @default.
• W2008657319 cites W2105407547 @default.
• W2008657319 cites W2110925491 @default.
• W2008657319 cites W2118819202 @default.
• W2008657319 cites W2118833232 @default.
• W2008657319 cites W2119239003 @default.
• W2008657319 cites W2119312052 @default.
• W2008657319 cites W2122826701 @default.
• W2008657319 cites W2126679757 @default.
• W2008657319 cites W2126832141 @default.
• W2008657319 cites W2128060680 @default.
• W2008657319 cites W2133959309 @default.
• W2008657319 cites W2136946092 @default.
• W2008657319 cites W2141529421 @default.

• next