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- W2008663231 abstract "5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of emotional, cognitive and behavioural control processes. However, its precise contribution is still not well understood. Depletion of 5-HT enhances behavioural and brain responsiveness to punishment or other aversive signals, while disinhibiting previously rewarded but now punished behaviours. Findings suggest that 5-HT modulates the impact of punishment-related signals on learning and emotion (aversion), but also promotes response inhibition. Exaggerated aversive processing and deficient response inhibition could underlie distinct symptoms of a range of affective disorders, namely stress- or threat-vulnerability and compulsive behaviour, respectively. We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects." @default.
- W2008663231 created "2016-06-24" @default.
- W2008663231 creator A5020886846 @default.
- W2008663231 creator A5067805366 @default.
- W2008663231 creator A5072571980 @default.
- W2008663231 date "2008-01-01" @default.
- W2008663231 modified "2023-10-01" @default.
- W2008663231 title "Serotoninergic regulation of emotional and behavioural control processes" @default.
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- W2008663231 doi "https://doi.org/10.1016/j.tics.2007.10.011" @default.
- W2008663231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18069045" @default.
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