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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008667095> ?p ?o ?g. }

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• W2008667095 abstract "Although primary CD8 responses to acute infections are independent of CD4 help, it is unknown whether a similar situation applies to secondary responses. We show that depletion of CD4 cells during the recall response has minimal effect, whereas depletion during the priming phase leads to reduced responses by memory CD8 cells to reinfection. Memory CD8 cells generated in CD4+/+ mice responded normally when transferred into CD4-/- hosts, whereas memory CD8 cells generated in CD4-/- mice mounted defective recall responses in CD4+/+ adoptive hosts. These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory." @default.
• W2008667095 created "2016-06-24" @default.
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• W2008667095 date "2003-04-11" @default.
• W2008667095 modified "2023-10-18" @default.
• W2008667095 title "Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory" @default.
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• W2008667095 doi "https://doi.org/10.1126/science.1082305" @default.
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