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- W2008667436 abstract "Malaria sporozoites have to cross the layer of sinusoidal liver cells to reach their initial site of multiplication in the mammalian host, the hepatocytes. To determine the sinusoidal cell type sporozoites use for extravasation, endothelia or Kupffer cells, we quantified sporozoite adhesion to and invasion of sinusoidal cells isolated from rat liver. In vitro invasion assays reveal that Plasmodium berghei and P. yoelii sporozoites attach to and enter Kupffer cells, but not sinusoidal endothelia. Unlike hepatocytes and other nonphagocytic cells, which are invaded in vitro only within the first hour of parasite exposure, the number of intracellular sporozoites in Kupffer cells increases for up to 12 hours. By confocal and electron microscopy, sporozoites are enclosed in a vacuole that does not colocalize with lysosomal markers. Inhibition of phagocytosis with gadolinium chloride has no effect on Kupffer cell invasion, but abolishes phagocytosis of inactivated sporozoites. Furthermore, sporozoites traverse in vitro from Kupffer cells to hepatocytes where they eventually develop into exoerythrocytic schizonts. Thus, malaria sporozoites selectively recognize and actively invade Kupffer cells, avoid phagosomal acidification, and safely passage through these phagocytes." @default.
- W2008667436 created "2016-06-24" @default.
- W2008667436 creator A5044010763 @default.
- W2008667436 date "2001-05-01" @default.
- W2008667436 modified "2023-10-15" @default.
- W2008667436 title "Malaria sporozoites actively enter and pass through rat Kupffer cells prior to hepatocyte invasion" @default.
- W2008667436 cites W102012657 @default.
- W2008667436 cites W1430181488 @default.
- W2008667436 cites W1481444703 @default.
- W2008667436 cites W1488703026 @default.
- W2008667436 cites W1515028535 @default.
- W2008667436 cites W1522576316 @default.
- W2008667436 cites W1532885046 @default.
- W2008667436 cites W1578786377 @default.
- W2008667436 cites W1734857180 @default.
- W2008667436 cites W1806079885 @default.
- W2008667436 cites W1902223278 @default.
- W2008667436 cites W1959562179 @default.
- W2008667436 cites W1972867498 @default.
- W2008667436 cites W1973187198 @default.
- W2008667436 cites W1981521423 @default.
- W2008667436 cites W1992616889 @default.
- W2008667436 cites W1996150072 @default.
- W2008667436 cites W2002915597 @default.
- W2008667436 cites W2004972574 @default.
- W2008667436 cites W2009372972 @default.
- W2008667436 cites W2011912863 @default.
- W2008667436 cites W2012423405 @default.
- W2008667436 cites W2014487710 @default.
- W2008667436 cites W2021528981 @default.
- W2008667436 cites W2024718588 @default.
- W2008667436 cites W2027143667 @default.
- W2008667436 cites W2029171425 @default.
- W2008667436 cites W2035257631 @default.
- W2008667436 cites W2036887760 @default.
- W2008667436 cites W2039832341 @default.
- W2008667436 cites W2040318556 @default.
- W2008667436 cites W2041151042 @default.
- W2008667436 cites W2047190365 @default.
- W2008667436 cites W2047988007 @default.
- W2008667436 cites W2052272127 @default.
- W2008667436 cites W2056334889 @default.
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- W2008667436 cites W2067180550 @default.
- W2008667436 cites W2067685740 @default.
- W2008667436 cites W2068728879 @default.
- W2008667436 cites W2070956951 @default.
- W2008667436 cites W2072039780 @default.
- W2008667436 cites W2072592385 @default.
- W2008667436 cites W2074739298 @default.
- W2008667436 cites W2075097215 @default.
- W2008667436 cites W2075465351 @default.
- W2008667436 cites W2078909808 @default.
- W2008667436 cites W2079037030 @default.
- W2008667436 cites W2087583564 @default.
- W2008667436 cites W2091284497 @default.
- W2008667436 cites W2092102383 @default.
- W2008667436 cites W2092173005 @default.
- W2008667436 cites W2099288361 @default.
- W2008667436 cites W2104072288 @default.
- W2008667436 cites W2133889010 @default.
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- W2008667436 cites W2155731278 @default.
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- W2008667436 cites W2162987583 @default.
- W2008667436 cites W2169294861 @default.
- W2008667436 cites W2170940087 @default.
- W2008667436 cites W2281584925 @default.
- W2008667436 cites W2322291575 @default.
- W2008667436 cites W2340228011 @default.
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- W2008667436 cites W2409073701 @default.
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- W2008667436 cites W282823973 @default.
- W2008667436 cites W3021017206 @default.
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- W2008667436 doi "https://doi.org/10.1053/jhep.2001.24237" @default.
- W2008667436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11343244" @default.
- W2008667436 hasPublicationYear "2001" @default.
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