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- W2008671967 abstract "Although numerous prospective randomized trials since the Veterans Administration studies clearly have attested to the efficacy and safety of antihypertensive therapy, there remain some controversial issues with all classes of antihypertensive drugs. Thiazide diuretics increase the risk for new-onset diabetes and their long-term safety has been questioned. Alpha-blockers do not reduce morbidity and mortality in uncomplicated hypertension but are well known to cause a variety of poorly tolerated side effects. The safety of calcium antagonists has been questioned for many years, although recent large prospective randomized trials such as Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, International Verapamil-Trandolapril Study, Intervention as a Goal in Hypertension, Valsartan Antihypertensive Long-Term Use Evaluation and the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) have attested to their safety and efficacy. Angiotensin-converting enzyme inhibitors, in general, are well tolerated but have potentially fatal adverse effects in a few patients. Angiotensin-receptor blockers are exceedingly well tolerated, but may be less-efficacious antihypertensive agents than other drug classes. Most antihypertensive drug classes have an effect on new-onset diabetes that should be taken into account in patients at risk. No head-to-head comparison of combination therapy looking at efficacy and safety has been available. The long-term safety of antihypertensive therapy is documented poorly because most trials only last 4 to 6 years. Despite these drawbacks and concerns, the benefits of antihypertensive therapy clearly outweigh its potential risk." @default.
- W2008671967 created "2016-06-24" @default.
- W2008671967 creator A5021945153 @default.
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- W2008671967 date "2005-07-01" @default.
- W2008671967 modified "2023-10-05" @default.
- W2008671967 title "Therapeutic Controversies in Hypertension" @default.
- W2008671967 cites W1510066062 @default.
- W2008671967 cites W1592471891 @default.
- W2008671967 cites W1604542334 @default.
- W2008671967 cites W1710832400 @default.
- W2008671967 cites W180946569 @default.
- W2008671967 cites W1965851278 @default.
- W2008671967 cites W1968680893 @default.
- W2008671967 cites W1971638152 @default.
- W2008671967 cites W1977607782 @default.
- W2008671967 cites W1979030376 @default.
- W2008671967 cites W1980089653 @default.
- W2008671967 cites W1980567021 @default.
- W2008671967 cites W1982920623 @default.
- W2008671967 cites W1983255569 @default.
- W2008671967 cites W1983526026 @default.
- W2008671967 cites W1986924251 @default.
- W2008671967 cites W1988192761 @default.
- W2008671967 cites W1993052853 @default.
- W2008671967 cites W1998245427 @default.
- W2008671967 cites W1998988712 @default.
- W2008671967 cites W1999904792 @default.
- W2008671967 cites W2001049748 @default.
- W2008671967 cites W2009980876 @default.
- W2008671967 cites W2021011733 @default.
- W2008671967 cites W2023412776 @default.
- W2008671967 cites W2023531846 @default.
- W2008671967 cites W2027812010 @default.
- W2008671967 cites W2028294998 @default.
- W2008671967 cites W2030168923 @default.
- W2008671967 cites W2030350015 @default.
- W2008671967 cites W2040888535 @default.
- W2008671967 cites W2044773944 @default.
- W2008671967 cites W2046774719 @default.
- W2008671967 cites W2050215103 @default.
- W2008671967 cites W2051576643 @default.
- W2008671967 cites W2054811823 @default.
- W2008671967 cites W2056893352 @default.
- W2008671967 cites W2056976690 @default.
- W2008671967 cites W2058645062 @default.
- W2008671967 cites W2061135005 @default.
- W2008671967 cites W2066169115 @default.
- W2008671967 cites W2071656461 @default.
- W2008671967 cites W2073756362 @default.
- W2008671967 cites W2078725437 @default.
- W2008671967 cites W2085252482 @default.
- W2008671967 cites W2088581697 @default.
- W2008671967 cites W2092805838 @default.
- W2008671967 cites W2093649691 @default.
- W2008671967 cites W2094856129 @default.
- W2008671967 cites W2097110468 @default.
- W2008671967 cites W2098780362 @default.
- W2008671967 cites W2100082183 @default.
- W2008671967 cites W2102979143 @default.
- W2008671967 cites W2106073810 @default.
- W2008671967 cites W2106609827 @default.
- W2008671967 cites W2109861453 @default.
- W2008671967 cites W2110831147 @default.
- W2008671967 cites W2114634962 @default.
- W2008671967 cites W2115156369 @default.
- W2008671967 cites W2116842056 @default.
- W2008671967 cites W2117939109 @default.
- W2008671967 cites W2118194784 @default.
- W2008671967 cites W2119369921 @default.
- W2008671967 cites W2126045082 @default.
- W2008671967 cites W2127254785 @default.
- W2008671967 cites W2128864868 @default.
- W2008671967 cites W2129967926 @default.
- W2008671967 cites W2133217116 @default.
- W2008671967 cites W2135038122 @default.
- W2008671967 cites W2137408480 @default.
- W2008671967 cites W2138119952 @default.
- W2008671967 cites W2138670606 @default.
- W2008671967 cites W2139805666 @default.
- W2008671967 cites W2143144750 @default.
- W2008671967 cites W2146851676 @default.
- W2008671967 cites W2147804563 @default.
- W2008671967 cites W2150409719 @default.
- W2008671967 cites W2152094259 @default.
- W2008671967 cites W2155699563 @default.
- W2008671967 cites W2156121263 @default.
- W2008671967 cites W2156225652 @default.
- W2008671967 cites W2157734027 @default.
- W2008671967 cites W2158132515 @default.
- W2008671967 cites W2161354300 @default.
- W2008671967 cites W2170390428 @default.
- W2008671967 cites W2172032309 @default.
- W2008671967 cites W2189592079 @default.
- W2008671967 cites W2203067263 @default.
- W2008671967 cites W22189248 @default.
- W2008671967 cites W2284554048 @default.
- W2008671967 cites W2305118939 @default.