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- W2008674053 abstract "The CHHC has experienced, to our knowledge, the first major outbreak of adenovirus type 7 disease in a children's hospital. At least 61 hospital employees and 7 patients were involved. Patients experienced a biphasic course which consisted of croup, diarrhea, fever, exudative pharyngitis, and/or conjunctivitis which preceded an acute respiratory decompensation by 1 wk. Those patients acquiring disease were individuals with compromised airways and underlying pulmonary pathology. Mortality from overwhelming viral pneumonia was 4/6 (67%). All fatal cases grew the organism from multiple sites including lung. Widespread illness appeared among hospital employees beginning 7 days after admission of the index case. History, NP and rectal viral cultures, and serology were obtained on 336/363 (94%) of staff working during the outbreak. Conjunctivitis was reported by 61 employees (16%), which was associated with corneal infiltrates in 5 (8%). 92/336 (27%) reported diarrhea and 221/336 (66%) reported URI symptoms. Control of viral transmission was achieved only when strict isolation precautions and cohorting of infected patients was combined with extensive screening of staff, and the temporary closure of the hospital to all new admissions. While adenovirus is a frequent community pathogen, this outbreak demonstrates that nosocomial type 7 infections in patients with pulmonary compromise frequently can be fatal." @default.
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- W2008674053 date "1981-04-01" @default.
- W2008674053 modified "2023-10-18" @default.
- W2008674053 title "497 A NOSOCOMIAL OUTBREAK OF FATAL ADENOVIRUS TYPE 7" @default.
- W2008674053 doi "https://doi.org/10.1203/00006450-198104001-00510" @default.
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