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- W2008676860 abstract "The efficiency of [2,9,17,23-tetrakis-(1,6-hexanedithiol)phthalocyaninato]zinc(II) as a photodynamic therapy (PDT) agent was investigated. This compound belongs to the second generation of photosensitizers currently tested for the cellular photo-damage of cancer cells. The production of reactive oxygen species (ROS) and phototoxicity of the photosensitizer were assessed. Healthy fibroblast cells and breast cancer (MCF-7) cells were treated with either free phthalocyanine or phthalocyanine bound to either gold nanoparticles or encapsulated in liposomes. Cell viability studies showed the optimum phototoxic effect on non-malignant cells to be 4.5 J cm(-2). The PDT effect of the liposome bound phthalocyanine showed extensive damage of the breast cancer cells. Gold nanoparticles only showed a modest improvement in PDT activity." @default.
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- W2008676860 date "2012-02-01" @default.
- W2008676860 modified "2023-09-23" @default.
- W2008676860 title "Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy" @default.
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- W2008676860 doi "https://doi.org/10.1016/j.jphotobiol.2011.11.007" @default.
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