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• W2008677145 abstract "The p38 mitogen-activated protein kinase pathway regulates innate immune responses in evolutionarily diverse species. We have previously shown that the Caenorhabditis elegans p38 mitogen-activated protein kinase, PMK-1, functions in an innate immune response pathway that mediates resistance to a variety of microbial pathogens. Here, we show that tir-1, a gene encoding a highly conserved Toll/IL-1 resistance (TIR) domain protein, is also required for C. elegans resistance to microbial pathogens. RNA interference inactivation of tir-1 resulted in enhanced susceptibility to killing by pathogens and correspondingly diminished PMK-1 phosphorylation. Unlike all known TIR-domain adapter proteins, overexpression of the human TIR-1 homologue, SARM, in mammalian cells was not sufficient to induce expression of NF-kappaB or IRF3-dependent reporter genes that are activated by Toll-like receptor signaling. These data reveal the involvement of a previously uncharacterized, evolutionarily conserved TIR domain protein in innate immunity that is functionally distinct from other known TIR domain signaling adapters." @default.
• W2008677145 created "2016-06-24" @default.
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• W2008677145 date "2004-04-27" @default.
• W2008677145 modified "2023-10-04" @default.
• W2008677145 title "Requirement for a conserved Toll/interleukin-1 resistance domain protein in the <i>Caenorhabditis elegans</i> immune response" @default.
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• W2008677145 doi "https://doi.org/10.1073/pnas.0308625101" @default.
• W2008677145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/404090" @default.
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