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- W2008678873 abstract "To assess the prevalence of Coronary Heart Disease (CHD) and Metabolic Syndrome (MS) in patients treated with antipsychotics.Retrospective, cross-sectional, multicenter study in which 117 Spanish psychiatrists (the CLAMORS Study Collaborative Group) recruited consecutive outpatients meeting DSM-IV criteria for Schizophrenia, Schizophreniform or Schizoaffective Disorder, receiving antipsychotic treatment for at least 12 weeks. CHD risk was assessed by SCORE (10-year CV death) and Framingham (10-year all CHD events) function. MS was defined by at least 3 of the following components: waist circumference > 102 (men)/> 88 (women) cm; triglycerides ≥ 150 mg/dl; HDL-cholesterol < 40 mg/dl (men)/< 50 mg/dl (women); blood pressure ≥ 130/85; fasting glucose ≥ 110 mg/dl.1452 evaluable patients (863 men, 60.9%), aged 40.7 ± 12.2 years (mean ± SD) were included. MS was present in 24.6% [23.6% (men), 27.2% (women); p = 0.130)]. The overall 10-year risks were 0.9 ± 1.9 (SCORE) and 7.2 ± 7.6 (Framingham). 8% (95%CI: 6.5–9.5) and 22.1% (95%CI: 20.0–24.3) of patients showed a high/very high risk according to SCORE (≥ 3%) and Framingham (≥ 10%) function. Abdominal obesity and low HDL-cholesterol were more prevalent in women: 54.5% (95%CI: 50.2–58.9) versus 34.3% (95%CI: 31.0–37.7), and 46.1% (95%CI: 41.4) versus 28.5 (95%CI: 50.8), p < 0.001 in both cases. Hypertension and hypertriglyceridemia were more prevalent in men: 59.0% (95%CI: 55.7–62.3) versus 46.0% (95%CI: 41.8–50.2), and 40.7% (95%CI: 37.2–44.2) versus 32.4 (95%CI: 28.3–36.5), p < 0.01 in both cases.CHD risk and MS prevalences among patients with schizophrenia treated with antipsychotics were in the same range as the Spanish general population 10 to 15 years older." @default.
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- W2008678873 date "2006-01-01" @default.
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- W2008678873 title "P.3.c.050 Psychopathology and metabolic syndrome (MS) in psychotic patients: the CLAMORS study" @default.
- W2008678873 doi "https://doi.org/10.1016/s0924-977x(06)70537-5" @default.
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