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- W2008679915 abstract "The process of sprouting angiogenesis requires that the endothelial cells degrade the basement membrane matrix and migrate into the interstitial matrix. Matrix metalloproteinases are enzymes capable of cleaving numerous extracellular matrix proteins. Increased production and activity of matrix metalloproteinases in any cell type is associated with a more migratory and invasive phenotype. This paper describes results of recent in-vitro studies of the regulation of transcription and activation of MMP-2 and MT1-MMP in endothelial cells, as well as studies that examined roles of matrix metalloproteinases in activity-induced angiogenesis.Key words: proteolysis, extracellular matrix, angiogenesis, mechanotransduction." @default.
- W2008679915 created "2016-06-24" @default.
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- W2008679915 date "2005-01-01" @default.
- W2008679915 modified "2023-10-15" @default.
- W2008679915 title "Endothelial cell regulation of matrix metalloproteinases" @default.
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- W2008679915 doi "https://doi.org/10.1139/y04-120" @default.
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