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• W2008682790 abstract "Null mutations of the proopiomelanocortin gene (Pomc) cause obesity in humans and rodents, but the contributions of central versus pituitary POMC deficiency are not fully established. To elucidate these roles, we introduced a POMC transgene (Tg) that selectively restored peripheral melanocortin and corticosterone secretion in Pomc mice. Rather than improving energy balance, the genetic replacement of pituitary POMC in PomcTg mice aggravated their metabolic syndrome with increased caloric intake and feed efficiency, reduced oxygen consumption, increased subcutaneous, visceral, and hepatic fat, and severe insulin resistance. Pair-feeding of PomcTg mice to the daily intake of lean controls normalized their rate of weight gain but did not abolish obesity, indicating that hyperphagia is a major but not sole determinant of the phenotype. Replacement of corticosterone in the drinking water of Pomc mice recapitulated the hyperphagia, excess weight gain and fat accumulation, and hyperleptinemia characteristic of genetically rescued PomcTg mice. These data demonstrate that CNS POMC peptides play a critical role in energy homeostasis that is not substituted by peripheral POMC. Restoration of pituitary POMC expression to create a de facto neuronal POMC deficiency exacerbated the development of obesity, largely via glucocorticoid modulation of appetite, metabolism, and energy partitioning." @default.
• W2008682790 created "2016-06-24" @default.
• W2008682790 creator A5007999324 @default.
• W2008682790 date "2006-01-19" @default.
• W2008682790 modified "2023-10-16" @default.
• W2008682790 title "Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice" @default.
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• W2008682790 doi "https://doi.org/10.1172/jci25243" @default.
• W2008682790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1386125" @default.
• W2008682790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16440060" @default.
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