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- W2008690634 abstract "This study shows that cocaine strengthens glutamatergic transmission, reduces K+ channel function and drives hyperexcitability in lateral habenula neurons projecting to the rostromedial tegmental nucleus. The authors also show that GluA1 trafficking mediates these cellular modifications and is instrumental in a drug-mediated depressive-like phenotype. Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K+ currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking." @default.
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- W2008690634 date "2015-02-02" @default.
- W2008690634 modified "2023-10-04" @default.
- W2008690634 title "Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula" @default.
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- W2008690634 doi "https://doi.org/10.1038/nn.3923" @default.
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