FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008692561> ?p ?o ?g. }

• W2008692561 endingPage "478" @default.
• W2008692561 startingPage "469" @default.
• W2008692561 abstract "The role of intestinal transporter regulation in optimising nutrient absorption has been studied extensively in rodent and cell line models but not in human subjects.The aim of the present study was to investigate the response in vivo of zinc transporters in the human enterocyte to dietary zinc supplementation.Eighteen patients who had previously undergone ileostomy, all free of any symptoms of inflammatory bowel disease.Subjects took a daily zinc supplement of 25 mg for 14 days in a double blind, placebo controlled, crossover trial. The effect of the supplement on expression in ileal biopsies of the zinc transporters SLC30A1, SLC30A4, SLC30A5, SLC39A1, SLC39A4, and metallothionein was measured by reverse transcription-polymerase chain reaction RT-PCR. Expression of SLC30A1, SLC30A5, and SLC39A4 was also examined by immunoblotting.The zinc supplement reduced SLC30A1 mRNA (1.4-fold) together with SLC30A1, SLC30A5, and SLC39A4 protein (1.8-fold, 3.7-fold, and to undetectable levels, respectively) in ileal mucosa and increased metallothionein mRNA (1.7-fold). The supplement had no effect on expression of SLC30A4 or SLC39A1 mRNA. Localisation of SLC30A5 at the apical human enterocyte/colonocyte membrane and also at the apical membrane of Caco-2 cells was demonstrated by immunohistochemistry. Commensurate with these observations in zinc supplemented human subjects, SLC30A1, SLC30A5, and SLC39A4 mRNA and protein were reduced in Caco-2 cells cultured at 200 muM compared with 100 muM zinc.These observations indicate that, in response to variations in dietary zinc intakes, regulated expression of plasma membrane zinc transporters in the human intestine contributes to maintenance of zinc status." @default.
• W2008692561 created "2016-06-24" @default.
• W2008692561 creator A5001517635 @default.
• W2008692561 creator A5002625911 @default.
• W2008692561 creator A5008375700 @default.
• W2008692561 creator A5008950466 @default.
• W2008692561 creator A5030574030 @default.
• W2008692561 creator A5032748020 @default.
• W2008692561 creator A5087386464 @default.
• W2008692561 date "2005-04-01" @default.
• W2008692561 modified "2023-10-15" @default.
• W2008692561 title "Homeostatic regulation of zinc transporters in the human small intestine by dietary zinc supplementation" @default.
• W2008692561 cites W135941159 @default.
• W2008692561 cites W1552886287 @default.
• W2008692561 cites W1561410732 @default.
• W2008692561 cites W1565162874 @default.
• W2008692561 cites W1568628619 @default.
• W2008692561 cites W1585106773 @default.
• W2008692561 cites W159459482 @default.
• W2008692561 cites W1612987016 @default.
• W2008692561 cites W167899168 @default.
• W2008692561 cites W1708684391 @default.
• W2008692561 cites W1860693578 @default.
• W2008692561 cites W1863197011 @default.
• W2008692561 cites W1893689834 @default.
• W2008692561 cites W1896814935 @default.
• W2008692561 cites W1929300075 @default.
• W2008692561 cites W1955702721 @default.
• W2008692561 cites W1964376836 @default.
• W2008692561 cites W1984632019 @default.
• W2008692561 cites W1987860556 @default.
• W2008692561 cites W2017725062 @default.
• W2008692561 cites W2029859548 @default.
• W2008692561 cites W2063667643 @default.
• W2008692561 cites W2064436345 @default.
• W2008692561 cites W2070584671 @default.
• W2008692561 cites W2075039014 @default.
• W2008692561 cites W2078091097 @default.
• W2008692561 cites W2098129388 @default.
• W2008692561 cites W2100090810 @default.
• W2008692561 cites W2105280572 @default.
• W2008692561 cites W2107862358 @default.
• W2008692561 cites W2131211659 @default.
• W2008692561 cites W2134310822 @default.
• W2008692561 cites W2157115338 @default.
• W2008692561 cites W2161407951 @default.
• W2008692561 cites W2166527836 @default.
• W2008692561 cites W2168684404 @default.
• W2008692561 cites W2187330547 @default.
• W2008692561 cites W2314747972 @default.
• W2008692561 cites W43291988 @default.
• W2008692561 doi "https://doi.org/10.1136/gut.2004.041962" @default.
• W2008692561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1774437" @default.
• W2008692561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15753530" @default.
• W2008692561 hasPublicationYear "2005" @default.
• W2008692561 type Work @default.
• W2008692561 sameAs 2008692561 @default.
• W2008692561 citedByCount "107" @default.
• W2008692561 countsByYear W20086925612012 @default.
• W2008692561 countsByYear W20086925612013 @default.
• W2008692561 countsByYear W20086925612014 @default.
• W2008692561 countsByYear W20086925612015 @default.
• W2008692561 countsByYear W20086925612016 @default.
• W2008692561 countsByYear W20086925612017 @default.
• W2008692561 countsByYear W20086925612018 @default.
• W2008692561 countsByYear W20086925612019 @default.
• W2008692561 countsByYear W20086925612020 @default.
• W2008692561 countsByYear W20086925612021 @default.
• W2008692561 countsByYear W20086925612022 @default.
• W2008692561 countsByYear W20086925612023 @default.
• W2008692561 crossrefType "journal-article" @default.
• W2008692561 hasAuthorship W2008692561A5001517635 @default.
• W2008692561 hasAuthorship W2008692561A5002625911 @default.
• W2008692561 hasAuthorship W2008692561A5008375700 @default.
• W2008692561 hasAuthorship W2008692561A5008950466 @default.
• W2008692561 hasAuthorship W2008692561A5030574030 @default.
• W2008692561 hasAuthorship W2008692561A5032748020 @default.
• W2008692561 hasAuthorship W2008692561A5087386464 @default.
• W2008692561 hasBestOaLocation W20086925611 @default.
• W2008692561 hasConcept C104317684 @default.
• W2008692561 hasConcept C126322002 @default.
• W2008692561 hasConcept C134018914 @default.
• W2008692561 hasConcept C149011108 @default.
• W2008692561 hasConcept C178790620 @default.
• W2008692561 hasConcept C185592680 @default.
• W2008692561 hasConcept C20719415 @default.
• W2008692561 hasConcept C2776531687 @default.
• W2008692561 hasConcept C2776928490 @default.
• W2008692561 hasConcept C2777882243 @default.
• W2008692561 hasConcept C2779604457 @default.
• W2008692561 hasConcept C535196362 @default.
• W2008692561 hasConcept C55493867 @default.
• W2008692561 hasConcept C71924100 @default.
• W2008692561 hasConcept C86803240 @default.
• W2008692561 hasConceptScore W2008692561C104317684 @default.
• W2008692561 hasConceptScore W2008692561C126322002 @default.
• W2008692561 hasConceptScore W2008692561C134018914 @default.
• W2008692561 hasConceptScore W2008692561C149011108 @default.

• next