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- W2008697493 abstract "Our previous work gave evidence that leopard frogs (Rana pipiens) possess inducible killer (IK) cells (CTL-like) and spontaneous killer (SK) cells (NK-like) that can destroy allogeneic RBC. To further characterize these cytotoxic cells we have examined their ultrastructural morphology and effector cell-target cell membrane contacts. We also studied the sensitivity of these two effector cells to low temperature (4°C). Our results showed that SK effector cells are lymphocytes (10 μm) which contain numerous vacuoles and osmiophilic granules, while IK effectors are another lymphocyte population (up to 12 μm) with a small amount of cytoplasm and few mitochondria. Both IK- and SK-mediated lytic responses were suppressed significantly by low temperature. These observations allow us to propose that frog SK and IK cells may be homologous to mammalian NK and CTL." @default.
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- W2008697493 date "1988-09-01" @default.
- W2008697493 modified "2023-09-23" @default.
- W2008697493 title "Ultrastructure of Cytotoxic Cells in Frogs" @default.
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- W2008697493 doi "https://doi.org/10.1111/j.1463-6395.1988.tb00909.x" @default.
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