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- W2008707237 abstract "Visual hallucinations (VHs) are common in Lewy body disease with dementia (LBD-D) including dementia with Lewy bodies (DLB) and Parkinson's disease (PD) with dementia (PDD), while those are not so frequently observed in Alzheimer's disease (AD). Recent neuropsychological studies have shown an association between visual cognitive impairments and VHs in LBD-D, and radionuclear studies have demonstrated decreased blood flow in the posterior lobe in those disorders. Based on these findings together, it is possible to speculate that visual information processing functions are selectively impaired in LBD-D, contributing, in part, to the pathophysiology of VHs. To clarify this issue and to examine whether neurophysiological evaluation of visual cognitive functions can differentiate LBD-D from AD, we compared DLB, PDD and AD patients with event-related potentials (ERPs). We compared visual and auditory ERP latencies among patients with PDD (17), DLB (24), and AD (21). Twenty healthy volunteers served as control subjects. The mean ages and MMS scores of the 3 patient groups were comparable. To elicit visual and auditory ERPs, a facial discrimination paradigm and a conventional auditory odd-ball paradigm, respectively, were used. The mean visual P3 latencies in the DLB and PDD groups were significantly or tended to be longer than that in the AD group, while the mean auditory P3 latencies in all three patient groups were comparable. When VP3/AP3 ratios were calculated to compare visual and auditory cognitive states, the PDD and DLB groups had larger ratios than other groups, and a significant difference was present between each of the two groups and the control group. With regard to the remaining parameters of the ERPs, the mean visual P2 latencies in the PDD and DLB groups were significantly longer than that in the control group. Our findings suggest that compared with AD patients, visual cognitive functions are selectively impaired in hallucinatory LBD-D patients. VHs may be associated in part with predominant visual cognitive impairments attributable to LBD pathologies. Our findings also suggest the clinical utility of visual and auditory ERP analyses in the differential diagnosis of LBD-D and AD." @default.
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- W2008707237 date "2010-07-01" @default.
- W2008707237 modified "2023-09-28" @default.
- W2008707237 title "P1-027: Visual information processing functions are selectively impaired in Lewy body disease with dementia, but not in Alzheimer's disease" @default.
- W2008707237 doi "https://doi.org/10.1016/j.jalz.2010.05.574" @default.
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