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W2008726073 abstract "ABSTRACT Objective quantication of disease specic neurodegenerative changes can facilitate diagnosis and therapeuticmonitoring in several neuropsychiatric disorders. Reproducibility and easy-to-perform assessment are essentialto ensure applicability in clinical environments. Aim of this comparative study is the evaluation of a fullyautomated approach that assesses atrophic changes in Alzheimers disease (AD) and Mild Cognitive Impairment(MCI).21 healthy volunteers (mean age 66.2), 21 patients with MCI (66.6), and 10 patients with AD (65.1) wereenrolled. Subjects underwent extensive neuropsychological testing and MRI was conducted on a 1.5 Tesla clinicalscanner. Atrophic changes were measured automatically by a series of image processing steps including state ofthe art brain mapping techniques. Results were compared with two reference approaches: a manual segmentationof the hippocampal formation and a semi-automated estimation of temporal horn volume, which is based uponinteractive selection of two to six landmarks in the ventricular system.All approaches separated controls and AD patients signicantly (10" @default.
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W2008726073 date "2008-03-06" @default.
W2008726073 modified "2023-09-26" @default.
W2008726073 title "Neurodegenerative changes in Alzheimer's disease: a comparative study of manual, semi-automated, and fully automated assessment using MRI" @default.
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W2008726073 doi "https://doi.org/10.1117/12.767455" @default.
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