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- W2008734585 abstract "An immunohistochemical examination of cultured corpus cavernosum cells of the rabbit showed that they were composed of many smooth muscle cells retaining -smooth muscle actin and a few of endothelial cells. Application of noradrenaline (NA, 0.5-100 microM) to the culture dose-dependently increased cytosolic concentrations of Ca2+ ([Ca2+]i) in smooth muscle cells. The NA (10 microM)-induced [Ca2+]i increase was dose-dependently inhibited by phenoxybenzamine (1 nM-1 microM). The inhibition was 71% at 0.1 microM and was completely made at 1 microM. An alpha(1)-adrenoceptor antagonist, prazosin (0.1 microM), inhibited the [Ca2+]i response by 42%, and propranolol (1 microM) enhanced the response by 118%. These adrenoceptor antagonists showed almost the same effects on a contractile response of corporal tissue strips to NA (10 microM) as the effects on the [Ca2+]i response. Our results suggest that NA-induced [Ca2+]i increase was mixed with a large increase through 1-adrenoceptors and a small decrease through beta-adrenoceptors. The increased [Ca2+]i could play a role of intracellular messenger for leading to contraction of cavernosal smooth muscle cells." @default.
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- W2008734585 date "2002-05-01" @default.
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- W2008734585 title "Effects of noradrenaline on cytosolic concentrations of Ca2+ in cultured corpus cavernosum smooth muscle cells of the rabbit" @default.
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- W2008734585 doi "https://doi.org/10.1016/s0304-3940(01)02579-4" @default.
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